Aging Clinical Trial
Official title:
Vitamin D and Resistance Exercise in Elderly
The aim of this randomized, double-blind, controlled intervention study with parallel groups
is to investigate the effect of resistance training (2x/week for 10 weeks) with and without
different goals of vitamin D intake on muscle strength, function and mass, oxidative stress
parameters and the immune system in community dwelling persons. Participants (n = 100) will
be community-dwelling older adults. After a preparticipation screening and a vitamin D blood
investigation (vitamin D status below 75 nmol/L) participants will be distributed randomly
but stratified by sex, age and initial vitamin D plasma levels to one of the 3 groups
(Vitamin D daily + strength training, Vitamin D monthly + strength training, no Vitamin D +
strength training).
Study participants are eligible if they are male or female with an age between 65 and 85
years and if their cognitive status as well as their physical fitness level allows to
participate at the strength training sessions. Exclusion criteria comprise chronic diseases
which contraindicate the training sessions, serious cardiovascular disease, diabetic
retinopathy and manifest osteoporosis, a frailty index at or above 3, medication with
anticoagulants or cortisone drugs, a regular strength training during the last six months and
a vitamin D plasma concentration of 75nmol/L or above.
Primary outcome measure is the change in the handgrip strength. Secondary outcome measures
comprise anthropometric data, functional performance tests, immunological and oxidative
stress parameters, DNA/Chromosomal damage microbiota, metabolomics and the nutritional
status.
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