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Metabolomics Profiling Research of Human Cerebrospinal Fluid in Aging Process

Aging Clinical Trial

Official title:
Metabolomics Profiling and Biomarker Research of Human Cerebrospinal Fluid in Aging Process and Age-related Neurodegenerative Diseases

Clinical Trial Summary

Perform quantitative metabolomics on human cerebrospinal fluid (CSF) samples and establish the first human CSF Metabolome Database of aging process in Taiwan.

Clinical Trial Description

Metabolomics is new science based on metabolite profiles in biofluids and tissues, which under bioinformatics approaches and analyses could help to characterize metabolomic status of CSF in aging process. In this prospective study, the investigators plan to enroll 200 health volunteers and 40 neurodegenerative diseases patients with received operation under spinal anesthesia. Blood and CSF samples will be analyzed using hydrogen-1 nuclear magnetic resonance (1H-NMR) and lipid chromatography-mass spectrometry (LC-MS). ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04315038
Study type Observational
Source Chang Gung Memorial Hospital
Contact
Status Completed
Phase
Start date August 1, 2019
Completion date July 31, 2021
View Details
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