Fitness and Longevity in Exercise — FLEX  

Aging Clinical Trial

Official title: Fitness and Longevity in Exercise

Status Completed

Clinical Trial Summary

The study objective was to determine the safety and efficacy of aerobic exercise in older HIV-infected men in a randomized trial comparing different levels of exercise intensity.

Clinical Trial Description

The study was a randomized trial of moderate-intensity versus high-intensity aerobic exercise (AEX) training in older HIV-infected adults. Funding was provided by K23 AG024896 (PI, Oursler) and the UMB Claude D. Pepper Older Americans Independence Center P60 AG12583 (PI, Goldberg).

The central hypothesis was that high-intensity AEX training is well-tolerated and significantly increases aerobic capacity in older HIV-infected adults.

The study met its objectives:

1. Scientific AIMS met:

1. High-intensity AEX training significantly increases aerobic capacity

2. Both moderate-intensity and high-intensity AEX training improve ambulatory function and endurance.

3. Activity of skeletal muscle oxidative enzymes is reduced, and associated with aerobic capacity.

2. Feasibility Objectives met:

1. AEX training is safe and well-tolerated in older HIV-infected adults.

2. Skeletal muscle punch biopsy is safe and well-tolerated in older HIV-infected adults.

3. Preliminary data was collected on plasma biomarkers of inflammation. ;

Related Conditions & MeSH terms

• Aging
• HIV-1-infection

• NCT number: NCT03399136
• Study type: Interventional
• Source: University of Maryland, Baltimore
• Status: Completed
• Phase: N/A
• Start date: July 19, 2007
• Completion date: April 23, 2012