Aging Clinical Trial
Official title:
Effects of Motor Imagery Practice Combined With Transcranial Direct Current Stimulation in the Learning of a Complex Motor Sequence in Young and Elderly Subjects
The mental repetition of movements - or motor imagery (MI) practice - facilitates motor
learning. It allows avoiding fatigue that occurs during physical practice; this method is
thus particularly interesting for elderly people. Transcranial direct current stimulation
(tDCS) is a noninvasive method of neurostimulation during which a low direct current is
applied to the brain via electrodes placed on the scalp. This method has been successfully
used to enhance motor learning in both young and elderly subjects.
The main aim of this study is to assess the impact of MI practice combined with tDCS on the
learning of a complex finger sequence, in young and elderly subjects.
For that purpose, young and elderly healthy subjects will be randomly assigned to Stimulation
and Sham groups. There will thus be a total of four groups: Young Stim, Young Sham, Elderly
Stim, and Elderly Sham.
All subjects will participate to three training sessions spread over five days, and a
retention test one week after the third training session.
During training they will mentally repeat a complex finger sequence with the left hand, for
13 min:
- Subjects of the Stimulation groups (Young Stim and Elderly Stim) will receive in
parallel an anodal tDCS of the primary motor cortex.
- Subjects of the Sham groups (Young Sham and Elderly Sham) will receive in parallel a
sham tDCS of the primary motor cortex.
Immediately before (pretest) and after (posttest) each training session, as well as during
the retention test, subjects will repeat the sequence as many times of possible, for 1 min.
During these tests (pretests, posttests and retention test) electroencephalographic activity
will be recorded to assess the Mu rhythm power.
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