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Osteoclast Inhibition and Bone Formation

Aging Clinical Trial

Official title:
Effects of Age and Osteoclast Inhibition on Bone Formation

Clinical Trial Summary

This protocol addresses: 1) How gene expression changes in bone cells are affected by aging? 2) Is aging associated with decreased signaling between bone cells? 3) How does treatment with the osteoporosis medication denosumab affect bone cell signaling?

Clinical Trial Description

This protocol collectively addresses the following goals: 1) What are the changes in gene expression in osteoblasts and osteocytes that lead to impaired bone formation with aging; 2) Since recent work from the investigators' group has demonstrated that osteoclasts produce a number of growth factors and cytokines (coupling factors) that enhance osteoblast proliferation and/or differentiation, is aging associated with reduced osteoclast coupling factor production; and 3) If osteoclasts are markedly reduced using the FDA-approved medication for osteoporosis, denosumab, how does that effect the quantity of coupling factors in the bone microenvironment and the target genes of these coupling factors in osteoblasts? ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02554695
Study type Interventional
Source Mayo Clinic
Contact
Status Completed
Phase Early Phase 1
Start date October 20, 2015
Completion date October 25, 2016
View Details
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