Aging Clinical Trial
Official title:
Ultrasonic Explorations of Cerebral Tissue Motions - Influence of Aging
The new technical of ultrasonic exploration of this project purpose to validate the measurement of cerebral pulsatility by a new way called "Fast Cerebral Pulsatility Imaging" (FCPI).This will somehow determine the natural history of cerebral pulsatility during development adult to old age
Main objective
Phase 1:
-Study the in-vivo development of ultrasonic method in terms of quality of the acquisitions
and intra-operator reproducibility.
Study the ease of positioning in relation to MRI and fusion of MRI and FCPI data via the
neuro-navigation system
Phase 2:
-Study the variability of cerebral pulsatility of measured by "Fast Cerebral Pulsatility
Imaging" or FCPI with age.
Secondary objectives
- Compare the results of displacements cartography's and vascular cartography obtained by
MRI (especially by Arteriel Spin Labelling = ASL)
- Compare results of FCPI with results of cognitive tests of aging separating fluid
functions (prefrontal) and functions called crystallized; and study the residual effect
of age on cognitive tasks and speed of cognitive processing after taking into account
the effect of the cerebral pulsatility
- Compare results of FCPI with electrophysiological measures (PE EEG) describing the
attentional control
- Perform an exploratory analysis to highlight the propagating part of the brain
displacement maps
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Health Services Research
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