Long-term Caloric Restriction and Cellular Aging Markers

Aging Clinical Trial

— CRONA  

Official title:

Caloric Restriction With Optimal Nutrition and Aging Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01256840
• Other study ID #: UCSF-CHR-10-01323
• Status: Completed
• Phase: N/A
• First received: December 2, 2010
• Last updated: October 9, 2017
• Start date: December 2010
• Est. completion date: August 2014

Study information

• Verified date: October 2017
• Source: University of California, San Francisco
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 71
• Est. completion date: August 2014
• Est. primary completion date: August 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Calorie restricting group: Self-reported caloric restriction for at least two years

• Calorie restriction group: BMI below 23

• Normal eating control: Normal eating (no history of caloric restriction) for two years

• Normal eating control: BMI below 30

• Obese comparison group: BMI above 30

• Obese comparison group: Normal eating (no history of caloric restriction) for two years

Exclusion Criteria:

• Regular smoker for the past six months

Related Conditions & MeSH terms

• Aging

Locations

Country	Name	City	State
United States	University of California	San Francisco	California

Sponsors (2)

Lead Sponsor	Collaborator
University of California, San Francisco	Robert Wood Johnson Foundation

Country where clinical trial is conducted

United States, 

References & Publications (2)

Incollingo Belsky AC, Epel ES, Tomiyama AJ. Clues to maintaining calorie restriction? Psychosocial profiles of successful long-term restrictors. Appetite. 2014 Aug;79:106-12. doi: 10.1016/j.appet.2014.04.006. Epub 2014 Apr 18. — View Citation

Tomiyama AJ, Milush JM, Lin J, Flynn JM, Kapahi P, Verdin E, Sinclair E, Melov S, Epel ES. Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study. Nutr Healthy Aging. 2017 Mar 31;4(2):147-156. doi: 10.3233/NHA-160017. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Telomere Length	This study is not a clinical trial, but the UCSF Committee on Human Research requires registration with clinicaltrials.gov. It is a ONE TIME POINT study, where we get a simple blood draw from people from three groups - calorie restricting, normal eating, and obese. Therefore, there IS NO FOLLOW UP/time frame. The outcome measure is assessed on the day of the study. Telomere length is a marker of cellular aging and is used to understand how the cells are aging. We will investigate whether long-term caloric restriction is associated cross-sectionally with longer telomere length (less aging).	One day

External Links

•   Clues to maintaining calorie restriction? Psychosocial profiles of successful long-term restrictors.
•   Long-term calorie restriction in humans is not associated with indices of delayed immunologic aging: A descriptive study.