Aging Clinical Trial
Official title:
Overcoming Inactivity in Older Adults: Impact on Vascular Homeostasis
Verified date | February 2019 |
Source | Medical College of Wisconsin |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The American Heart Association (AHA) and American College of Sports Medicine (ASCM) recommend
older adults (50≤ age ≤ 80) perform at least 30 minutes of moderate-intensity aerobic
exercise on most days ( ≥5 days) of the week. This suggestion arises, in part, from data
supporting that regular physical activity reduces the risk of adverse cardiovascular events A
portion of these benefits may be from reductions in the incidence and severity of
cardiovascular risk factors, including diabetes mellitus, obesity, and hypertension.
While this recommendation for physical activity has been in existence for almost 15 years,
the rates of obesity in the United States continue to rise and prevalence of sedentarism
remains at best unchanged. Researchers have been engaged in investigating novel interventions
to designed increase physical activity to reach the recommended activity targets. One
promising intervention involves use of inexpensive, easy to use pedometers that allow
individuals to objectively track the number of steps taken during a set period of time.
Recent data suggest that an average of 10,000 steps/day as measured by a pedometer accurately
estimates the activity levels recommended by the AHA, ASCM, and US government public health
guidelines.
While the benefits of habitual exercise are well-documented, there are no data that
demonstrate current recommendations for moderate physical activity in older adults by the
ASCM, AHA, and US public health guidelines reduce the risk of adverse cardiovascular events.
Interestingly, prior work indicates that pedometer-centered interventions can increase
physical activity, suggesting that this type of intervention could potentially lead to
cardiovascular benefits. Using validated surrogate markers of cardiovascular risk including
brachial artery endothelial function, tonometric measurements of vascular stiffness, and
measurements derived from transthoracic echocardiography, we will determine whether
increasing the physical activity of sedentary adults to an average of 10,000 steps or
more/day translates into improvements in cardiovascular health. This will be determined in
the context of a randomized control trial employing a control group, a study group that uses
a pedometer alone, and an intervention that couples a pedometer with internet-based
motivational messaging software demonstrated in our preliminary data to encourage older
adults to reach and exceed the 10,000 steps/day goal.
Status | Completed |
Enrollment | 114 |
Est. completion date | July 1, 2013 |
Est. primary completion date | July 1, 2013 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 50 Years to 90 Years |
Eligibility |
Inclusion Criteria: - Age = 50 and =90 years of age - Able to Ambulate without an Assist Device Exclusion Criteria: - History of Uncontrolled Diabetes Mellitus (Type 1 or 2) HgA1C >9.0% - Uncontrolled hypertension with a blood pressure greater than 160/100 mmHg at the screening visit. - Known history of chronic renal insufficiency, liver dysfunction, or cancer besides non-melanoma skin carcinomas or localized prostate cancer requiring systemic treatment within five years of enrollment. - Known history of cognitive impairment or inability to follow study procedures - History of limb amputation other than toes - History or Reynaud's Disease - Unable to button a shirt or blouse - Pregnancy |
Country | Name | City | State |
---|---|---|---|
United States | Medical College of Wisconsin | Milwaukee | Wisconsin |
Lead Sponsor | Collaborator |
---|---|
Medical College of Wisconsin | American Heart Association |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Flow induced Dilation of the Brachial Artery (FMD%) | 12 weeks | ||
Secondary | Left Ventricular Systolic Performance | Ventricular systolic stiffness and arterial elastance | 12 weeks | |
Secondary | Left Ventricular Diastolic Function | Use of multiple echocardiographic parameters to measure | 12 weeks |
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