Dietary Interventions for Muscle Mass

Aging Clinical Trial

Official title:

Dietary Interventions for Muscle Mass

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01145131
• Other study ID #: MEC 10-3-065
• Status: Completed
• Phase: N/A
• First received: June 15, 2010
• Last updated: September 13, 2011
• Start date: May 2011
• Est. completion date: June 2011

Study information

• Verified date: September 2011
• Source: Maastricht University Medical Center
• Contact: n/a
• Is FDA regulated: No
• Health authority: Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)
• Study type: Interventional

Clinical Trial Summary

Dietary intervention to prevent sarcopenia in elderly people. The objective of this study is to test whether meat structure plays an important role in protein digestion, to maximise the amino acid availability and to stimulate the muscle protein growth in elderly people.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 12
• Est. completion date: June 2011
• Est. primary completion date: June 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 65 Years to 85 Years

Eligibility

Inclusion Criteria:

• Non-obese male subjects (BMI<30) between the age of 65-85 years.

Exclusion Criteria:

• Type II diabetes or other known diseases, use of medication, female, other ages or BMI than indicated above, participation in any regular exercise program.

Study Design

Allocation: Randomized, Endpoint Classification: Bio-availability Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Aging

Intervention

Other:
• Intact or minced beef meat
135 gram piece of intact or minced beef meat, beef steak or minced beef resp.

Locations

Country	Name	City	State
Netherlands	Universiteit Maastricht, Bewegingswetenschappen	Maastricht	Limburg

Sponsors (1)

Lead Sponsor	Collaborator
Maastricht University Medical Center

Country where clinical trial is conducted

Netherlands, 

References & Publications (2)

Mioche L, Bourdiol P, Monier S, Martin JF, Cormier D. Changes in jaw muscles activity with age: effects on food bolus properties. Physiol Behav. 2004 Sep 30;82(4):621-7. — View Citation

Mioche L, Bourdiol P, Monier S. Chewing behaviour and bolus formation during mastication of meat with different textures. Arch Oral Biol. 2003 Mar;48(3):193-200. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Muscle protein synthesis	Muscle protein synthesis will be expressed as fractional synthetic rate (FSR) by dividing the increment in enrichment in the product, i.e. protein-bound D5phe tracer, by the enrichment of the precursor (=plasma availability).	6 h postprandial period	No
Secondary	Dietary amino acid plasma availability	The exogenous rate of phenylalanine appearance will be used to assess the bio-availability of dietary-protein derived amino acids in the circulation during the 6h postprandial period following meat intake	6h postprandial period	No

External Links

•   Information about research performed by the Maastricht Muscle Metabolism group at MUMC