Effects of Exercise and Cognitive Training on Cognitive Function in Older Adults

Aging Clinical Trial

Official title:

Neural Effects of Exercise, Cognitive, or Combined Training in AD At-Risk Elders

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01038726
• Other study ID #: NIH AG035775-01
• Status: Completed
• Phase: N/A
• First received: December 21, 2009
• Last updated: September 17, 2013
• Start date: December 2009
• Est. completion date: September 2012

Study information

• Verified date: September 2013
• Source: The Cleveland Clinic
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to gain a better understanding of the effects of exercise and cognitive training on improving brain function in healthy older adults who may be at risk for developing Alzheimer's Disease.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 108
• Est. completion date: September 2012
• Est. primary completion date: September 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 60 Years to 85 Years

Eligibility

Inclusion Criteria:

• First or Second-degree relative of someone with Alzheimer's Disease

• Not currently engaging in regular exercise

• Able to undergo an MRI

• Fluent in English

Exclusion Criteria:

• Neurological illnesses/conditions

• Medical illness/conditions that may affect brain function

• Any unstable or severe cardiovascular disease or asthmatic condition

• Severe depressive symptoms

• Inability to walk unassisted

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

• Aging
• Alzheimer Disease
• Alzheimer's Disease

Intervention

Other:
• Exercise Training
Aerobic exercise training program designed by the Cardiac Rehabilitation department
• Cognitive Training
Based on cognitive training program Brain Fitness®
• Flexibility Training
Non-aerobic flexibility training program designed by the Cardiac Rehabilitation department
• Educational Sessions
DVD-based educational programs on history, art, and literature

Locations

Country	Name	City	State
United States	The Cleveland Clinic	Cleveland	Ohio

Sponsors (2)

Lead Sponsor	Collaborator
The Cleveland Clinic	National Institutes of Health (NIH)

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain activation patterns measured by functional MRI		baseline and 12 weeks	No
Secondary	Neuropsychological Testing		baseline and 12 weeks	No
Secondary	Exercise assessment		baseline and 12 weeks	No