Aging Clinical Trial
Official title:
Exercise, Executive Processes and the Aging Brain
The purpose of this study is to assess the effect of aerobic exercise on the brain and cognition through the measurement of neuroelectric and behavioral indices of executive control cognitive function in older adults.
The aim of this research is to gain a better understanding of factors that relate to the
increased health and effective functioning of older adults. Specifically, efficiency of
psychomotor performance declines with advancing age leading to profound effects on older
adults' quality of life. For this reason, researchers have focused on the influence that
individual lifestyle habits have on the aging process. One lifestyle choice that has been
found to positively contribute to the efficiency of older adults' psychomotor performance is
cardiovascular exercise. This relationship appears to be especially significant when older
adults are challenged with more complex or effortful tasks. Previous research has led
investigators to believe that aging has a specific, rather than generalized, impact on
cognitive functioning. Also, prolonged participation in cardiovascular exercise has been
found to maintain the cognitive functioning critical for healthy aging.
Therefore, the purpose of this research is to examine the role of an organized 6-month
cardiovascular exercise intervention trial on electrocortical (event-related brain
potential) and behavioral measures (reaction time) of executive control. In addition, a
non-cardiovascular exercise control group that participates in a 6-month stretching and
toning program will be used for comparison. Participants will be measured before and after
exercise training during engagement in several tasks designed to elicit different executive
functions (e.g., discrimination, task switching, inhibition). Each task also contains a
non-executive condition that will be used for comparison to examine the specificity of
exercise participation of cognitive functioning. A secondary aim of this project is to
determine the effects of an acute bout of exercise on cognitive functioning. Both groups
will participate in several bouts of exercise followed by immediate measurement on the tasks
outlined above to determine whether acute exercise has beneficial effects on executive
processes. The significance of this research may include the increased understanding of
factors related to the amelioration of age-related decrements in central nervous system
functioning and recommendations for the maintenance of cognitive health during the later
stages of life.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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