Estrogen Use in Protection From Cognitive Decline

Aging Clinical Trial

Official title:

Estrogen Use in Protection From Cognitive Decline

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00097058
• Other study ID #: IA0063
• Secondary ID: R01AG022008SPO #
• Status: Completed
• Phase: N/A
• First received: November 17, 2004
• Last updated: November 17, 2014
• Start date: August 2003
• Est. completion date: November 2014

Study information

• Verified date: November 2014
• Source: Stanford University
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Federal Government
• Study type: Observational

Clinical Trial Summary

This study is designed to assess the effects of estrogen therapy among postmenopausal women at risk for cognitive decline.

Description:

A total of 71 postmenopausal women ages 50-65 on estrogen therapy will be randomized to continue or discontinue use of estrogen and will be followed for two years.

Participants will undergo PET and MRI scans and neuropsychological assessments initially and at the end of the two-year follow-up period. These procedures will allow us to evaluate brain metabolism and cognitive performance at baseline and two years following continuation or discontinuation of estrogen therapy.

We hypothesize that women who discontinue estrogen will show more evidence of decline than those who continue estrogen. This project will expand current knowledge of effects of estrogen by 1) determining whether estrogen use among postmenopausal women at risk for cognitive decline is protective of brain metabolism, 2) identifying early predictors for cognitive decline, and 3) developing guidelines for estrogen use in postmenopausal women.

Other known NCT identifiers

• NCT00238589

Recruitment information / eligibility

• Status: Completed
• Enrollment: 71
• Est. completion date: November 2014
• Est. primary completion date: November 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 45 Years to 65 Years

Eligibility

Inclusion Criteria:

• Women between the ages of 45 and 65

• Currently on hormone replacement

• One year or more post complete cessation of menses

• Willing to sign the Human Subject Protection Consent form prior to enrollment in the study

• Willing to be randomized to continue or discontinue estrogen therapy

• Adequately visually and auditorially acute to allow neuropsychological testing

• Beyond 8 years of educational achievement to allow adequate neuropsychological testing

• Willing to undergo brain imaging

• At risk for cognitive decline, as defined by one or more of the following: Personal or family history of mood disorder, Hypothyroidism, Diabetes, Family history of Alzheimer's, APOE-4 allele

Exclusion Criteria:

• Diagnosis of possible or probable Alzheimer's disease or dementia

• Cerebrovascular disease or uncontrolled hypertension (systolic BP >170 or diastolic BP >100)

• History of myocardial infarction within previous year or unstable heart disease

• History of significant liver disease, pulmonary disease, or current cancer

• Contraindication for MRI (metal in body, claustrophobia, etc.)

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Aging
• Cognition Disorders
• Menopause

Locations

Country	Name	City	State
United States	Stanford University School of Medicine, Dept. of Psychiatry and Behavioral Sciences	Stanford	California

Sponsors (2)

Lead Sponsor	Collaborator
Stanford University	National Institute on Aging (NIA)

Country where clinical trial is conducted

United States, 

References & Publications (3)

Dunkin J, Rasgon N, Wagner-Steh K, David S, Altshuler L, Rapkin A. Reproductive events modify the effects of estrogen replacement therapy on cognition in healthy postmenopausal women. Psychoneuroendocrinology. 2005 Apr;30(3):284-96. — View Citation

Rasgon NL, Small GW, Siddarth P, Miller K, Ercoli LM, Bookheimer SY, Lavretsky H, Huang SC, Barrio JR, Phelps ME. Estrogen use and brain metabolic change in older adults. A preliminary report. Psychiatry Res. 2001 Jul 1;107(1):11-8. — View Citation

Rasgon NL, Thomas MA, Guze BH, Fairbanks LA, Yue K, Curran JG, Rapkin AJ. Menstrual cycle-related brain metabolite changes using 1H magnetic resonance spectroscopy in premenopausal women: a pilot study. Psychiatry Res. 2001 Feb 28;106(1):47-57. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in cognition and brain metabolism		Baseline and 24 months	No