Aging Clinical Trial
Official title:
Memory Interventions for Older Adults
We have developed a training intervention that successfully improves older adults' memory. We
have also shown that older adults whose memory is as good as younger adults' memory (Hi-Old)
use an altered pattern of memory-related brain activity compared to younger adults, whereas
healthy older adults with poorer memory (Lo-Old) do not. We have also shown that individuals
with amnestic Mild Cognitive Impairment (aMCI) have impairments of conscious, effortful,
Recollection-based memory processes, whereas their automatic, Familiarity-based memory
processes are intact. Our primary current goal is to investigate whether our successful
memory intervention will improve Recollection and produce induce altered patterns of brain
activity in the Lo-Old and aMCI.
Young, Lo-Old, Hi-Old, and aMCI will be scanned using functional magnetic resonance imaging
while performing two memory tasks. Half of the Lo-Old and half of the aMCI will then receive
the memory intervention, while the other half in each group will receive a control program
consisting of information and games about aging. The Lo-Old and aMCI will then be rescanned
while performing the two memory tasks. We predict that the memory intervention will improve
performance on a number of memory tasks, and will induce altered patterns of brain activity.
In the Lo-Old, their brain activity after the memory intervention will look more like the
Hi-Old, while brain activity will become more focal in the aMCI.
n/a
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