Aging Disorder Clinical Trial
Official title:
The "Motoric Cognitive Risk" Syndrome in the Quebec Population: Results From the NuAge Study - Sub-study: The Biological Underpinnings of Motoric Cognitive Risk Syndrome: a Multicenter Study
The overall objective of the proposal is to examine the epidemiology of the newly reported "motoric cognitive risk" (MCR) syndrome, which is a pre-dementia syndrome combining subjective cognitive complaint (i.e.; memory complaint) with objective slow gait speed, in the Quebec elderly population. Cognition and locomotion are two human abilities controlled by the brain. Their decline is highly prevalent with physiological and pathological aging, and is greater than the simple sum of their respective prevalence, suggesting a complex age-related interplay between cognition and locomotion. Both declines in cognition and locomotion are associated, furthermore the temporal nature of their association has been unclear for a long time. Recently, a systematic review and meta-analysis has provided evidence that poor gait performance predicts dementia and, in particular, has demonstrated that MCR syndrome is a pre-dementia syndrome, suggesting that low gait performance is the first symptom of dementia. The uniqueness of MCR syndrome is that it does not rely on a complex evaluation or laboratory investigations. Indeed, this syndrome combined subjective cognitive complaint and objective slow gait speed, and is easy to apply in population-based settings. Prevalence and incidence of MCR syndrome, as well as its association with incidence of cognitive decline and impairment, have never been reported in Canada. Nutrition as a determinant of successful aging: The Quebec longitudinal Study (the NuAge study) is a Quebec population-based observational cohort study performed in healthy older community-dwellers adults which provides a unique opportunity to: 1) obtain reliable estimates of MCR syndrome prevalence and incidence, 2) determine the distribution of clinical and biological (blood biomarkers and genetic) characteristics associated with MCR syndrome, 3) examine the association of MCR syndrome and its biological characteristics with cognitive decline and incidence of cognitive impairment in the Quebec elderly population.
n/a
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT05961319 -
Smart Home Technologies for Assessing and Monitoring Frailty in Older Adults
|
||
Recruiting |
NCT04518423 -
Prevalence, Determinants and Natural History of Frailty and Pre-frailty in Elderly People
|
||
Completed |
NCT04321187 -
Influence of Prostate Cancer Radiation on Aging
|
||
Recruiting |
NCT04301713 -
Multifactorial Study of the Relationship Between the Conditions of Life and the Incidence of Risk of Falling
|
||
Completed |
NCT03704090 -
Non-pharmacological Prevention of Postoperative Delirium by Occupational Therapy Teams
|
N/A | |
Recruiting |
NCT04669782 -
Effect of Vitamin K Supplementation on Circulating Levels of Osteocalcin on the Bone Metabolism and Aging
|
N/A | |
Completed |
NCT06255431 -
EFFECTIVENESS AND SAFETY OF CREAM CONTAINING SPENT GRAIN WAX EXTRACT, ARGAN OIL, AND SHEA BUTTER POST-TRICHOLOROACETIC ACID 15% PEEL: RANDOMIZED, CONTROLLED, DOUBLE-BLIND, SPLIT-FACE CLINICAL TRIAL
|
Phase 4 | |
Not yet recruiting |
NCT06267625 -
Physical Impairments in Elderly Individuals
|
||
Not yet recruiting |
NCT05085535 -
Study of Manual Therapy Plus Therapeutic Exercise in Geriatrics
|
N/A | |
Completed |
NCT03345290 -
Impact of the Central Blood Pressure Level in Cerebral Metabolic Aging: a 18F-FDG PET Study.
|
N/A | |
Enrolling by invitation |
NCT03320005 -
EFFECTS OF RESISTANCE TRAINING IN ELDERLY
|
N/A | |
Recruiting |
NCT04026815 -
Health Status and Its Socio-economic Covariates of the Older Population in Poland - the Nationwide PolSenior2 Survey.
|
||
Recruiting |
NCT03702907 -
DC Longitudinal Study on Aging and Specimen Bank
|
||
Recruiting |
NCT06268132 -
Longevity in Russia
|
||
Recruiting |
NCT05552677 -
Effects of Multicomponent Training on Inflammation Parameters and Muscle Quality in Elderly Obese Woman
|
N/A | |
Not yet recruiting |
NCT03848897 -
Contribution of Virtual Reality and Modelling in Falling Risk Assessment in Elderly and Parkinson's Disease Patients
|
N/A | |
Completed |
NCT04151654 -
Effects of Footwear Suitability on Functional Performance and Balance in Elderly
|
N/A | |
Recruiting |
NCT04221282 -
ZEBinix® Retention Rate in Epilepsy in Elderly Patients
|
||
Recruiting |
NCT04169633 -
Spanish Adaptation and Validation of the Everyday Cognition Battery (ECB).
|