Ageing Clinical Trial
Official title:
Effects of Isoflavone Combined With Astaxanthin on Skin Aging
Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the
intrinsic aging process, and accounts for the majority of age-associated changes in skin
appearance. Reactive oxygen species (ROS) play a key role in UV-induced skin damage and
diminish skin matrix protein levels, leading skin aging. Strategies utilizing endogenous
skin antioxidants as well as plant-derived or synthetic compounds have been examined.
Astaxanthin mainly from marine algae and crustaceans is a kind of carotenoids which were
well-known photo-protective agents with strong antioxidant activity. Several studies have
revealed that supplementation of astaxanthin effectively protect skin against UV damage
through free radicals.
In addition, matrix metalloproteinase-1 induced by UV irradiation is an important step
toward skin aging. Recently, many studies pointed out that phytoestrogens exhibit agonistic
and antagonistic estrogen activities, suppressing activity of MMP-1 in skin. Isoflavone is a
kind of phytoestrogen from soybean and mainly act on skin and bones, inhibiting MMP-1
effectively.
The present study is designed to take isoflavone combined with astaxanthin to maximize their
anti-aging ability and objectively measure the effects of the mixture on facial wrinkles,
hydration, and elasticity.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
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