Generation 100: Blood Volume and Cardiac Function in Healthy Aging

Ageing Clinical Trial

Official title:

Generation 100: How Exercise Affects Mortality and Morbidity in the Elderly: A Randomized Control Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01765816
• Other study ID #: Gen-100-sub1
• Status: Completed
• Phase: N/A
• Start date: August 2012
• Est. completion date: November 2014

Study information

• Verified date: September 2020
• Source: Norwegian University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Hypothesis: Exercise will reduce morbidity and mortality rates in an elderly population. The extent of reduction will be intensity dependent.

As part of the "Generation 100" study, this sub-study project will investigate the effect of exercise on blood volume, cardiopulmonary health and heart function in healthy aging. Objective is to determine the acute effect of one endurance training session on blood volume in healthy elderly. The working hypothesis is that one interval training session increases total blood volume by 10% in healthy elderly, and that there will be no change after moderate continuous training.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: November 2014
• Est. primary completion date: February 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 70 Years to 75 Years

Eligibility

Inclusion Criteria:

• ability to walk at least 1km,

• born in 1938,1939,1940,1941 or 1942

• Sufficiently good health to be able to take part in the study, as determined by the researchers

Exclusion Criteria:

• Illness or disability that precludes exercise or hinders completion of the study

• Uncontrolled hypertension

• Symptomatic valve disease, hyper tropic cardio-myopathy or unstable angina

• Active cancer

• Test results indicating that study participation is unsafe

• Inclusion in other studies conflicting with participation in this one

Related Conditions & MeSH terms

• Ageing

Intervention

Behavioral:
• high intensity interval training

• moderate intensity training

Locations

Country	Name	City	State
Norway	Norwegian University of Science and Technology	Trondheim

Sponsors (1)

Lead Sponsor	Collaborator
Norwegian University of Science and Technology

Country where clinical trial is conducted

Norway, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	total blood volume	carbon monoxide-rebreathing spirometry (Bayreuth, Germany)	24 hours
Secondary	hemoglobin volume	carbon monoxide-rebreathing spirometry (Bayreuth, Germany)	24 hours

External Links

•   Generation 100 web page