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Clinical Trial Summary

Studying the morphology and function of the normal and diseased retina in vivo is needed for advancing the detection, diagnosis, and treatment of retinal disease. This protocol uses an adaptive optics scanning laser ophthalmoscope (AOSLO) to image the normal and diseased retina with individual cellular resolution non-invasively. The primary objective of this study is to obtain and analyze high-resolution images of the retina, in particular by imaging the cone photoreceptor mosaic, the retinal vasculature and other retinal layers. The study design will involve case-control studies, where cases are followed over time. Subjects age 7 and older may be invited to participate. The main research procedure involves retinal imaging with the AOSLO. The primary endpoint is the observation of differences in retinal images between subjects with and without retinal diseases. These changes will be quantified by examining the cell density, size, spacing and regularity of the cone photoreceptor mosaic, as well as examining the differences between other retinal layers.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT01866371
Study type Observational
Source University of Pennsylvania
Contact Jessica IW Morgan, PhD
Phone 215-614-4196
Email jwmorgan@pennmedicine.upenn.edu
Status Recruiting
Phase
Start date May 2013
Completion date December 2027

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