Adverse Effect Clinical Trial
Official title:
Efficacy and Safety of Weight-Based Insulin Titration (WEB-IT) Regimen Compared With Glucose Level-based Regimen in Hospitalized Patients With Type 2 Diabetes: A Randomized Controlled Study
The investigators propose to use a weight-based regimen consisting of basal-bolus insulin and preprandial rapid-acting insulin and to test its efficacy and safety in controlling blood glucose in hospitalized patients with type 2 diabetes.
Patients with type 2 diabetes are randomly assigned by computer-generated block randomization
to receive either weight-based or glucose level-based titration regimen. All antidiabetic
drugs are discontinued on admission.
Starting dose:
Total daily insulin is 0.4U/kg. Half is given as glargine and the remainder as aspart which
is divided into three equal parts used for three pre-meal boluses.
Titration:
1. Weight-based insulin titration regimen:
Glargine titration: 0.1U/kg per day when fasting blood glucose (FBG) is over 8.0 mmol/L.
Aspart titration: total dose 0.1U/kg per day when next pre-meal blood glucose (BG) is
over 8.0 mmol/L, which is divided into three equal parts adding to three pre-meal
boluses.
2. Glucose level- based titration regimen:
Glargine titration: 4, 6, or 8 U when FBG is, respectively, within the following ranges:
8.0-8.9, 9.0-9.9, >10.0 mmol/L.
Aspart titration: 1, 3, 5, 7 or 8 U when next pre-meal BG is, respectively, within the
following ranges: 8.0-10.9, 11.0-13.9, 14.0-16.9, 17.0-19.9, > 20 mmol/L.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05035888 -
Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension
|
N/A | |
| Completed |
NCT04028791 -
Sickle Cell Trait and Exercise, Effect of Hot Environment
|
N/A | |
| Completed |
NCT04556357 -
Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia
|
N/A | |
| Completed |
NCT04118322 -
The Effect of Peppermint Oil on Nausea, Vomiting and Retching in Cancer Patients Undergoing Chemotherapy
|
N/A | |
| Recruiting |
NCT03456544 -
Vancomycin-Associated Acute Kidney Injury: A Cross-Sectional Study From a Multi- Center in China
|
||
| Completed |
NCT03723109 -
Airway Management During TCI vs RSI Anesthesia Induction
|
||
| Completed |
NCT03316417 -
Study of Adverse Renal Effects of Immune Checkpoints Inhibitors
|
||
| Completed |
NCT05712018 -
Comparison of Different HES Coload Volumes on the 90% ED of Norepinephrine
|
N/A | |
| Not yet recruiting |
NCT04576663 -
Phenylephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia
|
N/A | |
| Completed |
NCT03006042 -
Pharmacokinetics of BPV Following Bilateral US-guided TAP Block for C-section
|
N/A | |
| Completed |
NCT03011775 -
Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease
|
Phase 4 | |
| Completed |
NCT04556370 -
Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia.
|
N/A | |
| Completed |
NCT03706755 -
Comparison of Two Doses of Norepinephrine in Preventing Hypotension After Spinal Anesthesia
|
Phase 4 | |
| Completed |
NCT02768168 -
The Effects of Dezocine Pretreatment on Dexamethasone Induced Perineal Irritation
|
N/A | |
| Completed |
NCT02854787 -
Intravenous Bolus of Phenylephrine vs. Norepinephrine in Preventing Hypotension After Spinal Anesthesia
|
Phase 4 | |
| Completed |
NCT04272567 -
Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension
|
N/A | |
| Recruiting |
NCT05310331 -
Donafenib for Recurrent Cervical Cancer
|
Phase 2 | |
| Completed |
NCT05690334 -
Different Crystalloid Coload Volumes on the 90% ED of Norepinephrine
|
N/A | |
| Not yet recruiting |
NCT06467045 -
Frequency of Adverse Events in Pediatric Patients Receiving Sedation for Magnetic Resonance Imaging
|
||
| Completed |
NCT05475873 -
Ondansetron for Postspinal Anesthesia Hypotension
|
N/A |