Clinical Trials Logo
  1. Home
  2. Adverse Effect
  3. NCT06151457

90% Effective Dose of Norepinephrine Infusions Under Intensive and Standard Treatment in Preeclamptic Patients

Adverse Effect Clinical Trial

Official title:
90% Effective Dose of Norepinephrine Infusions for Preventing Postspinal Anesthesia Hypotension Under Intensive and Standard Treatment in Preeclamptic Patients During Cesarean Section

Clinical Trial Summary

The objective of this study is to investigate the 90% effective dose of norepinephrine infusions for preventing postspinal anesthesia hypotension under intensive and standard treatment in preeclamptic patients during cesarean section

Clinical Trial Description

Post-spinal anesthesia hypotension is a frequent complication during spinal anesthesia for cesarean section. The incidence of post-spinal anesthesia hypotension is as high as 62.1-89.7% if prophylactic measures are not taken. The 2016 ASA guidelines for obstetric anesthesia suggest avoiding hypotension following spinal anesthesia in women and emphasize the use of vasopressors, specifically alpha-receptor agonists, as the preferred strategy to prevent and manage post-spinal anesthesia hypotension. The 2018 International Consensus in the United Kingdom and Northern Ireland recommends maintaining maternal systolic blood pressure above 90% of the baseline value following lumbar anesthesia, while avoiding dropping below 80% of the baseline value. Currently, the threshold for maintaining blood pressure above 80% of the baseline value is widely adopted as a standard; however, limited evidence supports the advantage of sustaining maternal blood pressure above 90% of the baseline value. The objective of this study is to investigate the 90% effective dose of norepinephrine infusions for preventing postspinal anesthesia hypotension under intensive and standard treatment in preeclamptic patients during cesarean section. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06151457
Study type Interventional
Source General Hospital of Ningxia Medical University
Contact Yi Chen, M.D.
Phone 86-951-674-3252
Email czzyxgp@163.com
Status Not yet recruiting
Phase N/A
Start date January 1, 2025
Completion date June 30, 2025
View Details
See also
  Status Clinical Trial Phase
Completed NCT05035888 - Prophylactic Norepinephrine and Phenylephrine Boluses for Postspinal Anesthesia Hypotension N/A
Completed NCT04028791 - Sickle Cell Trait and Exercise, Effect of Hot Environment N/A
Completed NCT04556357 - Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia N/A
Completed NCT04118322 - The Effect of Peppermint Oil on Nausea, Vomiting and Retching in Cancer Patients Undergoing Chemotherapy N/A
Recruiting NCT03456544 - Vancomycin-Associated Acute Kidney Injury: A Cross-Sectional Study From a Multi- Center in China
Completed NCT03723109 - Airway Management During TCI vs RSI Anesthesia Induction
Completed NCT03316417 - Study of Adverse Renal Effects of Immune Checkpoints Inhibitors
Completed NCT05712018 - Comparison of Different HES Coload Volumes on the 90% ED of Norepinephrine N/A
Not yet recruiting NCT04576663 - Phenylephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia N/A
Completed NCT03006042 - Pharmacokinetics of BPV Following Bilateral US-guided TAP Block for C-section N/A
Completed NCT03011775 - Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease Phase 4
Completed NCT04556370 - Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension in Parturients With Preeclampsia. N/A
Completed NCT03706755 - Comparison of Two Doses of Norepinephrine in Preventing Hypotension After Spinal Anesthesia Phase 4
Completed NCT02768168 - The Effects of Dezocine Pretreatment on Dexamethasone Induced Perineal Irritation N/A
Completed NCT02854787 - Intravenous Bolus of Phenylephrine vs. Norepinephrine in Preventing Hypotension After Spinal Anesthesia Phase 4
Completed NCT04272567 - Norepinephrine Prophylaxis for Postspinal Anesthesia Hypotension N/A
Recruiting NCT05310331 - Donafenib for Recurrent Cervical Cancer Phase 2
Completed NCT05690334 - Different Crystalloid Coload Volumes on the 90% ED of Norepinephrine N/A
Completed NCT05475873 - Ondansetron for Postspinal Anesthesia Hypotension N/A
Recruiting NCT03220919 - Efficacy and Safety of Weight-Based Insulin Titration Regimen in Hospitalized Patients With Type 2 Diabetes N/A