Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors

Status Recruiting

Clinical Trial Summary

Clinical Trial Description

This is a single-center trial in subjects with pancreatic cancer and other advanced solid tumors. It is an open-label, single arm dose escalation Phase IB trial with subjects accrued in a 3 subject dose escalation cohort. Subjects with treated advanced solid tumors, and showing disease progression on established standard therapy, will be enrolled in this trial. C3 (Simvastatin + Digoxin + Metformin) will be given as three oral pills within recommended package insert safe levels. Subjects will be accrued in 3-subject dose escalation cohorts. 3 additional subjects will be treated at the presumptive maximum effective cohort dose/schedule for a total of 6 subjects at maximum effective level. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03889795
Study type	Interventional
Source	University of Toledo
Contact	Danielle Mockensturm
Phone	419-383-6925
Email	danielle.mockensturm@utoledo.edu
Status	Recruiting
Phase	Phase 1
Start date	June 5, 2019
Completion date	December 30, 2026

View Details

See also
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