Everolimus in Treating Patients With Recurrent Low-Grade Glioma

Status Completed

Clinical Trial Summary

This phase II trial studies how well everolimus works in treating patients with recurrent low-grade glioma. Everolimus may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth or by blocking blood flow to the tumor.

Clinical Trial Description

PRIMARY OBJECTIVES:

1. To determine progression-free survival at 6 months associated with use of RAD001 (everolimus) in patients initially diagnosed with low-grade glioma who undergo biopsy or subtotal resection at the time of recurrence with pathologic evidence of recurrent low-grade glioma (LGG).

SECONDARY OBJECTIVES:

1. To further delineate the safety profile of RAD001 in patients with recurrent LGG.

2. To assess overall survival (OS) in patients treated with RAD001.

3. To assess the objective response rate (ORR) in patients treated with RAD001.

4. To assess the correlation of protein kinase B (PKB)/Akt and phosphatase and tensin homolog (PTEN) expression with response, progression status by 6 months, and OS in patients treated with RAD001. ;

Study Design

Related Conditions & MeSH terms

Adult Diffuse Astrocytoma
Adult Mixed Glioma
Adult Oligodendroglioma
Adult Subependymal Giant Cell Astrocytoma
Astrocytoma
Brain Neoplasms
Glioma
Oligodendroglioma
Recurrent Adult Brain Neoplasm

Clinical Trial Details

NCT number	NCT00823459
Study type	Interventional
Source	University of California, San Francisco
Contact
Status	Completed
Phase	Phase 2
Start date	January 23, 2009
Completion date	November 13, 2017

View Details

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