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Impact of Exogenous Estrogens on Cotisol Levels During Synacthen Stimulation

Adrenal Insufficiency Clinical Trial

Official title:
Betydning af Eksogent østrogen på Serum Kortisol Under Synacthen-stimulering Hos Hypogonade Kvinder Med Binyrebarkinsufficiens

Clinical Trial Summary

The aim is to investigate impact of exogenous estrogens on cotisol Levels during synacthen stimulation in female hypogonal patients on estrogen substitution. Both patients with and withour adrenal insufficiency will be studied

Clinical Trial Description

The aim is to investigate impact of exogenous estrogens on cotisol levels during synacthen stimulation in female hypogonal patients on estrogen substitution. Both patients with and without adrenal insufficiency will be studied . All patients (inclusion criteria age 18-50 years, BMI <35) will be followed for 6 months and have 3 synacthentests performed: One on transdermal estrogen (minimum 3 months), one on oral estrogens (min 3 months) and one without estrogen substitution for at least 3 months. Primary endpoint is change in serum cortisol 30 minutes after synacthen stimulation ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05302726
Study type Interventional
Source Rigshospitalet, Denmark
Contact
Status Enrolling by invitation
Phase N/A
Start date January 1, 2022
Completion date June 1, 2023
View Details
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