Study to Investigate Adrenal Crisis (Six-year Follow-up)

Status Completed

Clinical Trial Summary

Patients with adrenal insufficiency are at risk to suffer from life threatening adrenal crisis. The aim of this trial was to reevaluate the frequency of adrenal crisis and risk factors for crisis within a prospective study (six-years follow-up of a former prospective study).

Clinical Trial Description

Despite established hormone replacement therapy, patients with chronic adrenal insufficiency are at risk of suffering from life threatening adrenal crisis with a considerable mortality. A former prospective study revealed a frequency of about 8 adrenal crisis/ 100 patient years and a crisis associated mortality of 0.5 per 100 patient years for patients; furthermore, patients with a previous adrenal crisis were at higher risk of crisis. The aim of the current trial was to reevaluate the frequency of adrenal crisis and risk factors by contacting the patients of the initial prospective study (see above) within a six-years follow-up. Patients are contacted by questionnaire and additionally by phone (in case of an adrenal crisis or implausible statements). ;

Study Design

Related Conditions & MeSH terms

Adrenal Insufficiency

Clinical Trial Details

NCT number	NCT03499990
Study type	Observational
Source	Wuerzburg University Hospital
Contact
Status	Completed
Phase
Start date	August 13, 2016
Completion date	May 23, 2017

View Details

See also
Status	Clinical Trial	Phase
Enrolling by invitation	`NCT03282487` - Optimising Steroid Replacement in Patients With Adrenal Insufficiency	Phase 4
Not yet recruiting	`NCT05716607` - Treatment Study in Patients Treated With Both Insulin & Hydrocortisone	N/A
Recruiting	`NCT03399383` - Adherence in Chronic Adrenal Insufficiency	N/A
Completed	`NCT01428336` - Value of 25 mcg Cortrosyn Stimulation Test	N/A
Completed	`NCT00851942` - Determination of Method-specific Normal Cortisol and Adrenal Hormone Responses to the Short Synacthen Test	Phase 4
Withdrawn	`NCT00368381` - Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis	Phase 4
Active, not recruiting	`NCT04519580` - Improved Diagnostics and Monitoring of Polymyalgia Rheumatica
Recruiting	`NCT06008184` - Real-time Monitoring of Cortisol - Comparison of Cortisol Levels in Four Biological Fluids
Completed	`NCT03013166` - THIN Database Study: Resource Use and Outcomes in Patients With Adrenal Insufficiency Prescribed Hydrocortisone: Immediate, or Modified Release, or Prednisolone
Enrolling by invitation	`NCT02282150` - Modified-release Compared to Conventional Hydrocortisone on Diurnal Fatigue in Secondary Hypoadrenalism	Phase 4
Completed	`NCT02934399` - Dynamic Hormone Diagnostics in Endocrine Disease
Completed	`NCT03000231` - Circadian Function and Cardio-metabolic Risk in Adrenal Insufficiency
Completed	`NCT01960530` - An Investigational Study of Hydrocortisone	Phase 1
Completed	`NCT00552487` - Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis	N/A
Completed	`NCT00575341` - Dehydroepiandrosterone Substitution in Adolescent and Young Women With Central Adrenal Insufficiency	Phase 3
Completed	`NCT00471900` - Six Months DHEA Treatment in Female Adrenal Failure	N/A
Recruiting	`NCT03294876` - Rheumatoid Arthritis Adrenal Recovery Study
Completed	`NCT03709381` - Effect of Adrenocorticotropic Hormone on Vascular Endothelial Growth Factor Release in Children Study	Early Phase 1
Recruiting	`NCT05639127` - The Treatment of Adrenal Crisis With Inhaled Prednisolone	Early Phase 1
Completed	`NCT04488432` - Endocrine, Bone And Metabolic Disorders In Adults After Allogeneic Stem-cell Transplant