Adiposity Clinical Trial
Official title:
The Effect of Short-term Overconsumption of Specific Dietary Nutrients on Liver and Adipose Tissue Metabolism.
Despite work showing the overconsumption of saturated fatty acids (SFA) to be metabolically deleterious, debate continues about whether there is a link between SFA and cardiovascular disease risk. To explore this, we are undertaking a human in vivo parallel-design study, comparing two isocaloric high-fat diets; one enriched with SFA and the other enriched with unsaturated fatty acids (UFAs), to determine the impact of dietary fat composition on postprandial metabolism, liver fat, cardiac fat and cardiac function.
The investigators will recruit men and women with no medical condition or relevant drug therapy that affects lipid, glucose or liver metabolism. Purpose and design: The investigators are asking the research question: "How does the amount and type of fat consumed, influence liver fat content, cardiac function and postprandial fatty acid and liver fat metabolism when someone is not gaining or losing body weight?" To address this research question investigators want to undertake detail physiological studies, in a parallel dietary intervention, where individuals will have an MRI/S scans to assess liver fat, cardiac fat and cardiac function, along with a postprandial study day to assess how their metabolic response to a experimental test meal, before and then 28 days after consumption of a eucaloric, high fat intervention diet that will be either enriched in saturated or unsaturated fat. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT02558920 -
Meta-analyses of Food Sources of Fructose-Containing Sugars and Obesity
|
||
| Recruiting |
NCT04098679 -
Childhood Adiposity and Neurodevelopmental Outcomes Among Offspring of Women With Type 1 Diabetes (CONCEPTT Kids)
|
||
| Terminated |
NCT03631680 -
The Role of Estrogen in Adipocyte Remodeling Following Surgical Menopause
|
||
| Recruiting |
NCT05486338 -
Endoscopic Gastric Mucosal Ablation as a Primary Obesity Therapy
|
N/A | |
| Not yet recruiting |
NCT04096404 -
Gene-based Personalised Diet and Physical Activity Advice on Adiposity Indices Personalised Diet and Physical Activity Advice on Adiposity Indices in University Students
|
N/A | |
| Completed |
NCT02975258 -
Adiposity and Airway Inflammation in HIV-Associated Airway Disease
|
N/A | |
| Enrolling by invitation |
NCT01971840 -
Effectiveness of a Physical Activity Intervention on Preventing Obesity During the Adiposity Rebound Period.
|
N/A | |
| Completed |
NCT02151825 -
Effect of a Synbiotic on the Gut Microbiota and Adiposity-related Markers in Healthy Overweight Subjects
|
N/A | |
| Recruiting |
NCT05992688 -
The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)
|
N/A | |
| Active, not recruiting |
NCT03575897 -
Serial Assessment of Body Fat Accrual in Very Preterm Infants
|
N/A | |
| Completed |
NCT03642223 -
Central and Peripheral Adiposity and Iron Absorption
|
N/A | |
| Active, not recruiting |
NCT03542370 -
Umbrella Review of the DASH Dietary Pattern and Cardiometabolic Risk
|
||
| Completed |
NCT03898518 -
The Effects of a Jump Rope Exercise Program on Body Composition and Self-efficacy in Obese Adolescent Girls
|
N/A | |
| Recruiting |
NCT05324488 -
Diabetes Registry Graz for Biomarker Research
|
||
| Completed |
NCT02654535 -
Meta-analyses of Nuts and Risk of Obesity
|
||
| Completed |
NCT01922791 -
Nutrition and Pregnancy Intervention Study
|
N/A | |
| Recruiting |
NCT02041039 -
REWARD SYSTEM RESPONSES TO FOOD AROMAS
|
||
| Completed |
NCT03219125 -
Bone Marrow Adiposity and Fragility Fractures in Postmenopausal Women
|
||
| Recruiting |
NCT05433688 -
Study on the Performance of Symmcora® Mid-term Suture Versus Novosyn® Suture in Patients Undergoing Robotic Assisted Gastric Bypass Surgery
|
||
| Active, not recruiting |
NCT05654051 -
The SLIM LIVER Study
|
Phase 2 |