Adenoma Clinical Trial
Official title:
Does Fluorescence With or Without Indocyanine Green Improve Parathyroid Identification and Preservation
The aim of this study is to determine if fluorescence with or without indocyanine green can facilitate safe and accurate thyroid and parathyroid surgery.
The accurate identification of the parathyroid gland is a crucial aspect of thyroid and parathyroid surgery. Failing to recognize the parathyroid gland during thyroidectomy can result in the inadvertent removal of the gland, leading to postoperative hypocalcemia. On the other hand, during parathyroidectomy, there is a risk of mistaking other structures, such as lymph nodes, for parathyroid adenomas, which can leave the patient without a cure. Currently UAB employs intraoperative PTH or radioactive isotope techniques in conjunction with surgeon judgment. However, both methods have limitations, including being time-consuming, posing logistical challenges, and not providing feedback before gland removal. Parathyroid fluorescence is a relatively new technology. It was initially discovered that the parathyroid gland emits fluorescence, which distinguishes it from the surrounding tissues. Additionally, indocyanine green dye is readily taken up by the parathyroid gland, making its detection easy to the naked eye. Research has demonstrated that parathyroid fluorescence, with or without indocyanine green, is not only safe but also helps reduce postoperative hypocalcemia and locate lesions in patients with imaging-negative parathyroid adenomas. However, the current use of parathyroid fluorescence is not standardized, and further studies are needed to explore its clinical utility in terms of cure rates and postoperative complications. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT05551052 -
CRC Detection Reliable Assessment With Blood
|
||
| Recruiting |
NCT02545699 -
Prospective Trial to Compare ADR of G-EYE™ Colonoscopy With Standard Colonoscopy
|
N/A | |
| Completed |
NCT01802008 -
Comparison of Adenoma Detection Miss Rates at Colonoscopy Associated With Different Withdrawal Times
|
N/A | |
| Recruiting |
NCT01211132 -
Cap Assisted Colonoscopy for the Detection of Colon Polyps
|
N/A | |
| Completed |
NCT04287335 -
Multitarget Stool FIT-DNA Study for Colorectal Cancer Early Screening in China
|
||
| Not yet recruiting |
NCT06398418 -
R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients With Solid Tumors
|
Phase 1 | |
| Recruiting |
NCT05362344 -
Colorectal Cancer Screening in Cystic Fibrosis
|
||
| Completed |
NCT03268200 -
The Effect of Segmental Re-examination of Colon for Adenoma Detection in Colonoscopy
|
N/A | |
| Recruiting |
NCT04591145 -
Multi-center Validation of a Deep Learning Based Bowel Preparation Evaluation System
|
||
| Completed |
NCT02978664 -
The Impact of Distraction on Adenoma Detection Rate
|
N/A | |
| Completed |
NCT00018551 -
Chemoprevention With Folic Acid
|
Phase 2 | |
| Recruiting |
NCT05594576 -
Comparison of the ENDOCUFF VISION® Endoscopy Cap Coupled With GI GENIUS™ Artificial Intelligence Compared to Each Device Alone in Improving Colonic Adenoma Detection Rate During Colonoscopy
|
N/A | |
| Not yet recruiting |
NCT04135716 -
A Multicenter Study Evaluating the Effectiveness of Endo.Angel in Improving the Quality of Colonoscopy
|
N/A | |
| Recruiting |
NCT02552017 -
Accuracy of Detection Using ENdocuff Optimisation of Mucosal Abnormalities
|
N/A | |
| Recruiting |
NCT02288962 -
Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas
|
Phase 3 | |
| Completed |
NCT02066064 -
G-Eye Advanced Colonoscopy For Increased Polyp Detection Rate-randomized Tandem Study With Different Endoscopist
|
N/A | |
| Completed |
NCT01749722 -
Safety and Efficacy of the NaviAid™ G-Eye System During Colonoscopy
|
N/A | |
| Withdrawn |
NCT01546259 -
Water Method in Low-body Mass Index (BMI) Female Patients With Unsedated Colonoscopy
|
N/A | |
| Withdrawn |
NCT01546246 -
Water Method in Patients With Incomplete Colonoscopy
|
N/A | |
| Withdrawn |
NCT01546220 -
Water Method in Elder Patients With Unsedated Colonoscopy
|
N/A |