Clinical Trials Logo
  1. Home
  2. Adenoma
  3. NCT02288962

Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas

Adenoma Clinical Trial

Official title:
Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas (NFPAs) - a Randomized Controlled Trial

Clinical Trial Summary

Due to lack of hormone overproduction in non-functioning pituitary adenomas (NFPAs), only the symptomatic adenomas or large adenomas with proven growth and risk for symptoms in near future will undergo pituitary surgery. The remaining adenomas are monitored regularly. Operation of these large adenomas will rarely remove all tumour tissue, and there is also a risk of worsening of pituitary function. Often, adenomas with the highest growth potential are operated several times and some also need radiation therapy, providing additional risk for pituitary failure. Unlike some of the hormone-producing adenomas, there is no established pharmacological treatment for NFPAs. However, there are a few non-randomized studies suggesting that treatment with dopamine agonists may slow growth, and also induce tumour shrinkage. At present, cabergoline is the dopamine agonist most widely used in the treatment of pituitary adenomas secreting prolactin. Aim is to study the effect of medical treatment with cabergoline in non-functioning pituitary adenomas on the change in tumour volume.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02288962
Study type Interventional
Source St. Olavs Hospital
Contact Stine L Fougner, md phd
Email stine.fougner@ntnu.no
Status Recruiting
Phase Phase 3
Start date November 2014
Completion date December 2027
View Details
See also
  Status Clinical Trial Phase
Active, not recruiting NCT05551052 - CRC Detection Reliable Assessment With Blood
Recruiting NCT02545699 - Prospective Trial to Compare ADR of G-EYE™ Colonoscopy With Standard Colonoscopy N/A
Completed NCT01802008 - Comparison of Adenoma Detection Miss Rates at Colonoscopy Associated With Different Withdrawal Times N/A
Recruiting NCT01211132 - Cap Assisted Colonoscopy for the Detection of Colon Polyps N/A
Completed NCT04287335 - Multitarget Stool FIT-DNA Study for Colorectal Cancer Early Screening in China
Not yet recruiting NCT06398418 - R-5780-01 In Combination With PD-1 Checkpoint Inhibitors (Checkpoint Protein on Immune Cells Called T Cells) in Patients With Solid Tumors Phase 1
Recruiting NCT05362344 - Colorectal Cancer Screening in Cystic Fibrosis
Completed NCT03268200 - The Effect of Segmental Re-examination of Colon for Adenoma Detection in Colonoscopy N/A
Recruiting NCT04591145 - Multi-center Validation of a Deep Learning Based Bowel Preparation Evaluation System
Completed NCT02978664 - The Impact of Distraction on Adenoma Detection Rate N/A
Completed NCT00018551 - Chemoprevention With Folic Acid Phase 2
Recruiting NCT05594576 - Comparison of the ENDOCUFF VISION® Endoscopy Cap Coupled With GI GENIUS™ Artificial Intelligence Compared to Each Device Alone in Improving Colonic Adenoma Detection Rate During Colonoscopy N/A
Not yet recruiting NCT04135716 - A Multicenter Study Evaluating the Effectiveness of Endo.Angel in Improving the Quality of Colonoscopy N/A
Recruiting NCT02552017 - Accuracy of Detection Using ENdocuff Optimisation of Mucosal Abnormalities N/A
Completed NCT02066064 - G-Eye Advanced Colonoscopy For Increased Polyp Detection Rate-randomized Tandem Study With Different Endoscopist N/A
Completed NCT01749722 - Safety and Efficacy of the NaviAid™ G-Eye System During Colonoscopy N/A
Withdrawn NCT01546246 - Water Method in Patients With Incomplete Colonoscopy N/A
Completed NCT01485133 - Water Method Colonoscopy in Patients With Prior Surgery N/A
Withdrawn NCT01546220 - Water Method in Elder Patients With Unsedated Colonoscopy N/A
Withdrawn NCT01546259 - Water Method in Low-body Mass Index (BMI) Female Patients With Unsedated Colonoscopy N/A