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Pilot Study of DRibble Vaccine for Prostate Cancer Patients — DRibble  

Adenocarcinoma of the Prostate Clinical Trial

Official title:
A Pilot Study of DPV-001 DRibble Vaccine With Imiquimod in Advanced Prostate Cancer

Clinical Trial Summary

This is a pilot study of the DRibble vaccine in patients with advanced prostate cancer.

Clinical Trial Description

The primary objective of this pilot study is to assess the safety and tolerability of DRibble vaccine, cyclophosphamide, imiquimod, and Ceravix in castrate resistant prostate cancer.

This study will also assess:

- the immune profile of tumor biopsy specimens if sites amenable to biopsy are present

- humoral and cellular responses to cancer antigens after DRibble vaccination

- the response to a reporter antigen vaccine (Ceravix) after DRibble vaccination

An exploratory objective is to characterize the microbiome before and after study drugs administration and correlate prostate cancer responses. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02234921
Study type Interventional
Source UbiVac
Contact
Status Completed
Phase Phase 1
Start date October 24, 2014
Completion date August 15, 2018
View Details
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