Gamified Adaptive Approach Bias Modification on Individuals With Methamphetamine Use History

Addiction, Substance Clinical Trial

Official title:

Gamified Adaptive Approach Bias Modification on Individuals With Methamphetamine Use History

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05794438
• Other study ID #: TS001
• Status: Completed
• Phase: N/A
• Start date: March 10, 2023
• Est. completion date: July 15, 2023

Study information

• Verified date: July 2023
• Source: Adai Technology (Beijing) Co., Ltd.
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

A randomized controlled trial will be conducted to investigate whether a proposed algorithm that adjusts the congruency ratio based on the user's performance and difficulty can enhance the effectiveness of approach bias modification. Methamphetamine users will be recruited and randomized into an algorithm group, a standard group, and a control group.

Description:

To assess the efficacy of an adaptive approach bias modification (A-ApBM) paradigm with gamified designs and dynamic difficulty adjustments in reducing cue-induced craving in individuals with methamphetamine use history. DESIGN: Randomized controlled trial with three study groups: Adaptive ApBM (A-ApBM), Static ApBM (S-ApBM), and control. A-ApBM and S-ApBM groups engaged in ApBM training using a smartphone application for four weeks. A-ApBM used an adaptive algorithm to dynamically adjust the difficulty level based on individual performance, while S-ApBM had a static difficulty level. Cue-induced craving scores were assessed using a visual analog scale at baseline, post-intervention, and at week-16 follow-up.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 139
• Est. completion date: July 15, 2023
• Est. primary completion date: July 15, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 55 Years

Eligibility

Inclusion Criteria:

• having a history of methamphetamine use of at least one year

Exclusion Criteria:

• could not fluently operate an Android or an iOS smartphone

• having mental health conditions other than MUD

Related Conditions & MeSH terms

• Addiction, Substance
• Substance-Related Disorders

Intervention

Behavioral:
• Static Approach Bias Modification
In the static approach bias modification, users were instructed to swipe upward when they see portrait format images and swipe downward when they see landscape format images. A shrinking animation comes after swiping upward to simulate the visual effect of moving away (approach), and a growing animation comes after swiping downward to simulate the visual effect of moving towards (avoidance). Two types of images, namely drug-related and non-drug-related, were used in the training. The drug-related images were related to methamphetamine (methamphetamine crystals, powders, and paraphernalia), and the non-drug-related images were related to healthy lifestyles (wealth, sports, gourmet, family activities, etc).
• Adaptive Approach Bias Modification
In the adaptive approach bias modification, users were instructed to swipe upward when they see portrait format images and swipe downward when they see landscape format images. A shrinking animation comes after swiping upward to simulate the visual effect of moving away (approach), and a growing animation comes after swiping downward to simulate the visual effect of moving towards (avoidance). Two types of images, namely drug-related and non-drug-related, were used in the training. The drug-related images were related to methamphetamine (methamphetamine crystals, powders, and paraphernalia), and the non-drug-related images were related to healthy lifestyles (wealth, sports, gourmet, family activities, etc). An algorithm continuously monitors the performance of the user and adjusts the ratio of congruent and incongruent trials accordingly to attain a desired difficulty curve.

Locations

Country	Name	City	State
China	Gao Ping Town Community Drug Rehabilitation Center	Guanghan	Sichuan
China	Han Zhou Street Community Drug Rehabilitation Center	Guanghan	Sichuan
China	Jin Lun Town Community Drug Rehabilitation Center	Guanghan	Sichuan
China	Jin Yan Street Community Drug Rehabilitation Center	Guanghan	Sichuan
China	Jin Yu Town Community Drug Rehabilitation Center	Guanghan	Sichuan
China	Lian Shan Town Community Drug Rehabilitation Center	Guanghan	Sichuan
China	Nan Feng Town Community Drug Rehabilitation Center	Guanghan	Sichuan
China	San Shui Town Community Drug Rehabilitation Center	Guanghan	Sichuan
China	Sanxingdui Town Community Drug Rehabilitation Center	Guanghan	Sichuan
China	SixTwentySix Service Center, Luo Cheng Street, Guanghan City	Guanghan	Sichuan
China	Xiang Yang Town Community Drug Rehabilitation Center	Guanghan	Sichuan
China	Xiao Han Town Community Drug Rehabilitation Center	Guanghan	Sichuan

Sponsors (1)

Lead Sponsor	Collaborator
Adai Technology (Beijing) Co., Ltd.

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Cue induced craving for methamphetamine	The cue-induced craving was assessed by showing the participants images related to methamphetamine (methamphetamine crystals, powders, and paraphernalia) on a smartphone and asking them to rate their cravings on a 0-10 visual analog scale (0 being least craved and 10 being most craved).	Baseline
Primary	Cue induced craving for methamphetamine	The cue-induced craving was assessed by showing the participants images related to methamphetamine (methamphetamine crystals, powders, and paraphernalia) on a smartphone and asking them to rate their cravings on a 0-10 visual analog scale (0 being least craved and 10 being most craved).	Immediately Post-intervention
Primary	Cue induced craving for methamphetamine	The cue-induced craving was assessed by showing the participants images related to methamphetamine (methamphetamine crystals, powders, and paraphernalia) on a smartphone and asking them to rate their cravings on a 0-10 visual analog scale (0 being least craved and 10 being most craved).	16 week from baseline assesment