Addiction Opiate Clinical Trial
Official title:
Deep Brain Stimulation of the Bilateral Nucleus Accumbens for Patients With Methadone Maintenance Treatment
Methadone maintenance treatment (MMT) is one of the main forms of treatments for opioid
dependence. Despite its effectiveness and widespread use, people will experience withdrawal
if daily dose is insufficient or missed, promoting reluctance to attempt detoxification. In
addition, methadone is a full opioid agonist which can induce respiratory depression or
sedation without ceiling level, so overdose usage can be fatal. Hence, an alternative therapy
is needed to completely reduce the carving for drugs and to relieve the negative affective
sate caused by withdrawal.
Deep brain stimulation (DBS) is a reasonable treatment approach for addiction. Since 2009 the
first case report emerged, the nucleus accumbens (NAc) is still the only brain target to be
investigated in clinical case series of DBS for alcohol and heroin addiction.
This research will mainly investigate the effectiveness and safety of NAc-DBS for patients
with methadone maintenance treatment. The investigators will also explore the influence of
NAc-DBS on brain activity and cognition.
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