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Acute Respiratory Failure clinical trials

View clinical trials related to Acute Respiratory Failure.

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NCT ID: NCT05670093 Recruiting - Clinical trials for Acute Respiratory Failure

Neural Pressure Support, Synchrony and Respiratory Muscle Unloading

NPS
Start date: May 17, 2022
Phase: N/A
Study type: Interventional

In this study patients who are intubated and on ventilator for more than 24h will be ventilated at three different level of support in Pressure Support and Neural Pressure Support to study patient-ventilator synchrony and muscle unloading.

NCT ID: NCT05577221 Completed - Clinical trials for Acute Respiratory Failure

High Flow During Weaning From Mechanical Ventilation

FLOWEAN
Start date: February 17, 2023
Phase: N/A
Study type: Interventional

Detection and relief of dyspnea in mechanically ventilated patients is a priority. Optimization of mechanical ventilation settings is unfortunately often insufficient to relieve dyspnea in patients entering the weaning process. Pharmacological treatments are effective but their use is likely to delay separation with the ventilator. Promoting the development of non-pharmacological interventions is therefore an interesting avenue. The hypothesis is that the application of high-flow humidified nasal air in orotracheally intubated patients can decrease the work of breathing and relieve dyspnea at the time of weaning from mechanical ventilation. Patients will be exposed to stepwise increase in high flow nasal air (0 L/min, 30 L/min, 50 L/min and 70 L/min) before to undergo a 60 minutes spontaneous breathing trial. During the protocol, dyspnea, inspiratory effort, respiratory drive, respiratory muscles electromyogram (EMG) and patient's comfort will be assessed.

NCT ID: NCT05570903 Not yet recruiting - Clinical trials for Acute Respiratory Failure

A Prospective Observational Cohort Study of Awake Prone Position Ventilation Strategy in Patients With Acute Respiratory Failure

Start date: October 10, 2022
Phase:
Study type: Observational

Awake prone positioning has been used widely for patients with COVID-19.Many research results are not uniform on the key issue of whether the prognosis of patients can be improved,and most of the subjects were patients with SARS-CoV-2 infected who are not intubated.The investigators will conduct a prospective observational study on patients with acute respiratory failure induced by various causes to determine whether awake prone position can reduce the need to upgrade to invasive mechanical ventilation and improve the prognosis of patients compared with standard treatment.

NCT ID: NCT05566652 Recruiting - Clinical trials for Acute Respiratory Failure

Neural Pressure Support for Low Pulmonary Compliance

NPS_LowCrs
Start date: December 1, 2022
Phase: N/A
Study type: Interventional

With this interventional prospective study, we aim at comparing the effectiveness of Neural Pressure Support (NPS) in reducing respiratory work and patient-ventilator asynchronies as compared with standard Pressure Support Ventilation (PSV), in a cohort of patients with Acute Respiratory Failure (ARF) and low respiratory system compliance.

NCT ID: NCT05540834 Recruiting - Clinical trials for Acute Respiratory Failure

Viscoelastic Testing Guided Tissue Plasminogen Activator Treatment in Acute Respiratory Failure

VETtiPAT-ARF
Start date: May 18, 2022
Phase: Phase 2
Study type: Interventional

Patients with coronavirus disease (COVID) and non-COVID acute respiratory failure (ARF) may be at an increased risk of thrombosis due to increased clot formation and decreased clot lysis. This two stage study aims to utilise bedside coagulation technology to detect patients at increased risk and guide tPA treatment to maximise efficacy and safety through a personalised approach.

NCT ID: NCT05523479 Enrolling by invitation - Clinical trials for Acute Respiratory Failure

The Maximizing Extubation Outcomes Through Educational and Organizational Research (METEOR) Trial

METEOR
Start date: March 1, 2023
Phase: N/A
Study type: Interventional

The METEOR Trial will compare four implementation strategies-traditional online education, protocol-directed care, interprofessional education, and a combination of protocol-directed care and interprofessional education-to test the hypotheses that interprofessional education is superior to traditional online education as an implementation strategy in the intensive care unit (ICU) and the benefits of interprofessional education are increased when interprofessional education is paired with a clinical protocol. Additionally, the trial will also test the hypothesis that preventive post-extubation NIV for high-risk patients and preventive post-extubation HFNC for low-risk patients are both superior to current clinical practice (i.e., conventional post-extubation oxygen therapy).

NCT ID: NCT05467332 Not yet recruiting - Clinical trials for Acute Respiratory Failure

Tracheal Positive Pressure During High Flow Nasal Oxygen Administration in Critically Ill Patients: a Physiologic Study.

HPEEP
Start date: April 2023
Phase:
Study type: Observational

High flow nasal cannula administration in critically ill patients is frequently used to improve acute respiratory failure or to prevent respiratory failure after extubation. It acts generating a mild positive pressure in the airways and by reducing respiratory effort of patients. However to the best of our knowledge, no study to date has directly measured the amount of positive pressure generated in the trachea of patients. The primary aim, therefore, of this study measures this positive pressure after extubation in critically ill patients.

NCT ID: NCT05464277 Recruiting - Clinical trials for Traumatic Brain Injury

Intermediate Normal Versus High Normal Oxygen Levels in the Emergency Department for Severe Traumatic Brain Injury

INACHOS
Start date: December 2, 2022
Phase: N/A
Study type: Interventional

Despite almost universal usage of supplemental oxygen therapy in patients presenting in the emergency department with traumatic brain injury (TBI), optimal oxygen levels are unclear. The investigators propose a pilot multi-center randomized controlled trial to test the hypothesis that maintaining intermediate normal as opposed to high normal oxygen levels in patients presenting in the emergency department with TBI is feasible, and to obtain preliminary data on the efficacy of the two approaches to oxygen therapy. The aim is that the investigators produce pilot data, which could inform the design of potential subsequent larger clinical trials.

NCT ID: NCT05451342 Recruiting - Clinical trials for Acute Respiratory Distress Syndrome

Explore Potential Plasma and BALF Immunometabolic and Lipidomic Biomarkers for Identifying ARDS Endotypes

Start date: February 15, 2022
Phase:
Study type: Observational

Acute respiratory distress syndrome (ARDS) is a life-threatening condition that causes high mortality (41% to 58%). Previous studies have reported that biomarkers can facilitate phenotypic diagnosis of ARDS, enabling precision treatment of ARDS. Although there were many studies that found some potential therapeutic targets for ARDS, no pharmacotherapies have been validated to treat ARDS. The development of biomarkers to predict the prognosis and monitor the response to treatment would be of interest for selecting patients for specific therapeutic trials. Many recent studies have shown that immune metabolic changes are involved in the pathogenesis of ARDS and may become a new therapeutic target for them. We aimed to identify a panel of immunometabolic and lipidomic biomarkers derived from blood and bronchoalveolar lavage fluid (BALF) which may help differentiate the ARDS endotypes.

NCT ID: NCT05423301 Recruiting - Clinical trials for Acute Respiratory Failure

Global Physiotherapy in ICU Patients With High Risk Extubation Failure

KINEXTUB
Start date: September 15, 2023
Phase: N/A
Study type: Interventional

This study aims to compare care provided by physiotherapists, combining respiratory care and early rehabilitation in intensive care unit, with standard care on the rate of acute respiratory failure within 7 days after extubation, in patients with high risk of extubation failure.