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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT03634787
Other study ID # 158200-17-941-455
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date October 20, 2017
Est. completion date December 30, 2021

Study information

Verified date August 2018
Source Vilnius University
Contact Kestutis Strupas, Prof. MD/PhD
Phone +37052365000
Email kestutis.strupas@santa.lt
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

To investigate the role of Heat Shock Proteins in the mechanism of acute severe pancreatitis. In addition to test the potential treatment target of acute pancreatitis.

All patients who present with clinical symptoms of acute pancreatitis are evaluated for the enrollment of the study.


Description:

All patients with acute pancreatitis are evaluated according to modified Atlanta classification acute pancreatitis severity scores.

Blood serum, urine and DNA samples are collected from all patients presented on admission, after 24 hours, 48 hours, 72 hours.

CT is performed in al patients to evaluate necrosis of pancreas Day 5-7 since hospital admission. If necrosis is not present follow-up is stopped.


Recruitment information / eligibility

Status Recruiting
Enrollment 280
Est. completion date December 30, 2021
Est. primary completion date December 2021
Accepts healthy volunteers
Gender All
Age group 18 Years to 100 Years
Eligibility Inclusion Criteria:

- no prior diagnosis of acute pancreatitis

- admission to the hospital within 2 days since the clinical symptoms

- confirmed diagnosis of acute pancreatitis

Exclusion Criteria:

- chronic pancreatitis

- pancreatic cancer

Study Design


Related Conditions & MeSH terms


Intervention

Diagnostic Test:
CT Scan Day 5-7
Computed Tomography on Day 5-7 according to a clinical protocol.

Locations

Country Name City State
Lithuania Vilnius University Hospital "Santaros Klinikos Vilnius

Sponsors (1)

Lead Sponsor Collaborator
Vilnius University

Country where clinical trial is conducted

Lithuania, 

Outcome

Type Measure Description Time frame Safety issue
Primary To measure the levels of heat shock proteins in serum and plasma in acute severe pancreatitis settings Different molecular weight Heat Shock proteins role while developing acute pancreatitis. 2 years
Secondary To measure pancreas cells activity while applying Heat Shock Protein inhibitors To establish a mechanism explaining the potential use of heat shock proteins inhibitors/ activators for treatment of acute pancreatitis 2 years
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