Acute Pain Clinical Trial
Official title:
An Exploratory Study of the Epigenetic Influences on Post-Surgical Acute and Chronic Pain
Pain is the way our brain interprets certain bodily sensations. It is very difficult to
describe or to put into words as perception and tolerance of pain varies widely between
individuals. It is known that age, gender and past experience and memory of past experience
all contribute to patients' feelings of discomfort and tolerance of pain, but the reason why
some patients actually do not experience any pain at all post surgery is still unknown.
Because pain affects every person at some point in their lives, it is of utmost importance
that we can find more effective analgesic methods, and provide analgesia tailored to an
individual's need as well as discovering new methods which may be able to identify those
individuals who are more prone to suffering serious, or chronic pain. It has been proposed
that epigenetic modifications may play a role in sensitivity to analgesia and response to
trauma, such as post surgery. The effects of epigenetic changes on key genes and the role
this plays in analgesia sensitivity and pain perception is deserving of further research.
Epigenetics is a growing field of study in which there are genetic modifications that do not
involve changes to base sequences in a gene, but that result nonetheless in changes to gene
expression. It has long been known that changes in gene expression play an important role in
the establishment of pain states. But it is not known whether a priming injury can induce
lasting epigenetic marks which would result in an increase in both postoperative acute pain
and the risk for chronic pain. Only by fully understanding these epigenetic mechanisms will
we be able to offer better drugs for the treatment of pain, and to identify those at high
risk of postoperative pain and postsurgical chronic pain.
The purpose of this study is to determine whether severity of pain following surgical
procedures, such as third molar surgery is related to baseline methylation status of the
promoter region of IL-6 and TNF-α and changes in methylation status post surgery.
Status | Recruiting |
Enrollment | 120 |
Est. completion date | November 2014 |
Est. primary completion date | September 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - Patient requires third molar surgery for case group and patient does not require surgery for control group - Age 18 or above - Ability to read and understand the study information and consent form - Written consent obtained Exclusion Criteria: - Patient does not requires third molar surgery for case group and patient requires third molar surgery for control group - Age below 18 - Major cognitive or psychiatric disorders that affect the ability to complete study - Refuse to participate |
Observational Model: Case Control, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
Hong Kong | Department of Anaesthesiology, The University of Hong Kong | Hong Kong | |
Hong Kong | Department of Anaesthesiology, The University of Hong Kong | Hong Kong |
Lead Sponsor | Collaborator |
---|---|
The University of Hong Kong |
Hong Kong,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | pain score | From postoperative 1 hour to postoperative 3 months | No | |
Secondary | IL-6 and TNF-a expression | From postoperative 1 hr to postoperative 3 month | No |
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