Acute Myeloid Leukemia Clinical Trial
Official title:
IDH1/2 Mutational Analysis in AML Patients: Diagnosis and Follow-up
In a spanish series of AML patients it is intended to perform, at the moment of diagnosis,
pyrosequencing of IDH1 and IDH2 genes. Taking into account the incidence of AML in the area,
it is planed to study 100 patients per year.
Among the cases with IDH1/2 mutations, targeted deep sequencing (TDS) of a panel covering
coding regions of 40 myeloid related genes will be applied. With TDS, pyrosequencing results
will be validated at the same time that prognosis value of co-mutated genes could be studied.
Furthermore, with TDS, molecular architecture of IDH1 and IDH2 mutated cases might be better
understood.
n/a
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