| Eligibility |
Inclusion Criteria:
1. Patients with confirmed diagnosis of acute myeloid leukemia (AML) who are refractory*
to induction therapy and not eligible for further intensive induction therapy based on
documented medical reasons (e.g. disease characteristics or patient characteristics),
or
2. Patients with confirmed diagnosis of acute myeloid leukemia (AML) who are refractory*
to induction therapy and not immediate candidates for allogeneic HSCT (bridge to
transplant is allowed)
*refractory to induction therapy is defined as no CR, no CRi and no PR (according to
standard criteria, see Section 11.2.3) after at least one intensive induction therapy
including at least 5 days of cytarabine 100-200 mg/m² continuously or an equivalent
regimen with cytarabine with total dose not less than 500 mg/m² per cycle and at least
2 days of an anthracycline (e.g. daunorubicin, idarubicin).
3. Age = 60; no upper age limit
4. ECOG performance status of = 2 at screening
5. To control hyperleukocytosis or extramedullary involvement, medication with
hydroxyurea is allowed up to 24h before start of study treatment. In case of
hyperleukocytosis hydroxyurea should be given and start of study treatment should be
delayed until leukocyte counts are < 20 x 10^9/L.
6. Female subjects of childbearing potential* may participate, providing they meet the
following conditions:
- Have a negative pregnancy test (serum or urine with a sensitivity of at least 25
mIU/mL; local laboratory) within 72 hours prior to starting study therapy. They
must agree to ongoing pregnancy testing during the course of the study, and after
end of study therapy. This applies even if the subject practices true
abstinence** from heterosexual contact.
- Agree to practice true abstinence** from heterosexual contact (which must be
reviewed on a monthly basis) or agree to use, and be able to comply with two
effective methods of contraception (e.g., oral, injectable, or implantable
hormonal contraceptive; tubal ligation; intra-uterine device; barrier
contraceptive with spermicide; or vasectomized partner) without interruption
during the study therapy (including dose interruptions), and for 3 months after
discontinuation of study drugs.
- A female subject of childbearing potential (FCBP) is a female who: 1) has
achieved menarche at some point 2) has not undergone a hysterectomy or
bilateral oophorectomy or 3) has not been naturally postmenopausal
(amenorrhea following cancer therapy does not rule out childbearing
potential) for at least 24 consecutive months (ie, has had menses at any
time in the preceding 24 consecutive months).
- True abstinence is acceptable when this is in line with the preferred
and usual lifestyle of the subject. Periodic abstinence (eg, calendar,
ovulation, symptothermal, postovulation methods) and withdrawal are not
acceptable methods of contraception.
7. Male patients with a female partner of childbearing potential must agree to abstain
from sexual intercourse or to the use of at least two effective contraceptive methods
(e.g., synthetic condoms with spermicide, etc) at screening and throughout the course
of the study and should avoid fathering a child during the course of the study and for
3 months following the last study treatment.
8. Signed written informed consent.
Exclusion Criteria:
1. Known or suspected hypersensitivity to the study drugs and/or any excipients
2. Patients with acute promyelocytic leukemia exhibiting t(15;17)(q22;q12); PML-RARA, or
with variant translocations
3. Acute myeloid leukemia (AML) with isocitratdehydrogenase (IDH) 1 or 2 mutations if
results are available from the central AMLSG reference laboratories
4. ECOG performance status > 2
5. Inadequate cardiac, hepatic and/or renal function at Screening Visit defined as:
1. heart failure NYHA II-IV
2. unstable angina pectoris
3. total bilirubin, ALT, AST > 2.5 x upper normal serum level
4. Creatinine > 1.5 x upper normal serum level
6. Active central nervous system involvement
7. Uncontrolled infection
8. Uncontrolled diabetes mellitus
9. Patients with a "currently active" second malignancy requiring active therapy other
than non-melanoma skin cancers (except for hormonal/antihormonal treatment, e.g. in
prostate or breast cancer)
10. Patients with "currently active" bladder cancer or bladder cancer in their history,
patients with risk factors for bladder cancer (e.g. exposure to aromatic amines or
heavy tobacco smoker), or macrohematuria of unknown origin
11. Severe neurological or psychiatric disorder interfering with ability of giving an
informed consent
12. Known or suspected active alcohol or drug abuse
13. Known positive for HIV, active HBV or HCV infection
14. No consent for registration, storage and processing of the individual disease
characteristics and course as well as information of the family physician and/or other
physicians involved in the treatment of the patient about study participation.
15. Treatment with any other clinical study drug within 14 days before the first
administration of the investigational drugs or at any time during the study
16. Breast feeding woman or women with a positive pregnancy test at Screening Visit
17. Male patients with a female partner of childbearing potential not willing to abstain
from sexual intercourse or to the use of at least two effective contraceptive methods
(e.g., synthetic condoms with spermicide, etc) at screening and throughout the course
of the study and for 3 months following the last study treatment.
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