Acute Myeloid Leukemia Clinical Trial
molecular relapse in t (8; 21) acute myeloid leukemia (AML) after allogeneic stem cell
transplantation (allo-SCT) is still a problem even after donor lymphocyte infusion.
Interferon seemed to augment graft-versus-leukemia (GVL) effect in this part of patients.
the study is to evaluate the safety and efficacy of interferon for the intervention of
molecular relapse in t (8; 21) acute myeloid leukemia (AML) after allogeneic stem cell
transplantation (allo-SCT)
| Status | Recruiting |
| Enrollment | 40 |
| Est. completion date | October 2017 |
| Est. primary completion date | October 2017 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | N/A to 65 Years |
| Eligibility |
Inclusion Criteria: - high risk t (8; 21) AML - molecular relapse after allo-SCT Exclusion Criteria: - active graft-versus-host disease - uncontrolled severe infection - organ function failure |
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Country | Name | City | State |
|---|---|---|---|
| China | Peking University People's Hospital | Beijing |
| Lead Sponsor | Collaborator |
|---|---|
| Peking University People's Hospital |
China,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | relapse rate | number of participants with morphologic relapse at one year | participants will be followed for an expected average of 365 days | No |
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