Acute Mesenteric Ischemia Clinical Trial
— SurvibioOfficial title:
Searching Biomarkers of Acute Intestinal Ischemic Injuries
The aim of the SURVIBIO study is to characterize accurate biomarkers for acute mesenteric ischemia, in particular at early stages. In the study, the development of biomarkers will be based on the analysis of human biological samples from patients and controls that will be conserved in a biological library. Samples will be analysed in the Laboratory for Vascular Translational Sciences (LVTS, Inserm U1148), in the Department of Biochemistry (Pr Puy, Dr Peoc'h), in Paris V university , in Imperial College of London (Pr Dumas), in Jacques Monod Institute and in Maastricht University Medical Center . The candidate markers will be determined according to an a priori method (form markers already described in the literature) and with no a priori strategy using -omics methods.
Status | Recruiting |
Enrollment | 556 |
Est. completion date | July 30, 2028 |
Est. primary completion date | December 31, 2027 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - age> 18 years - Acute abdominal pain requiring an injected abdominal injected CT scan, at best at non-injected / early arterial / portal time - Admitted or attended in Beaujon and / or Bichat hospitals - Patient covered by a social security scheme - Written consent Exclusion Criteria: • lack of abdominal CT scan |
Country | Name | City | State |
---|---|---|---|
France | Corcos Olivier | Clichy |
Lead Sponsor | Collaborator |
---|---|
Assistance Publique - Hôpitaux de Paris |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | observation of clinical-bio-scanographic pain related to a splanchnic-mesenteric, occlusive or non-occlusive vascular insufficiency, to abdominal CT angiography, in the absence of another identifiable cause | 2 years | ||
Secondary | mortality and causes | 2 years | ||
Secondary | Intestinal resection ratio | 2 years | ||
Secondary | acute intestinal ischemic injury relapse ratio | 2 years | ||
Secondary | short gut syndrome features | 2 years | ||
Secondary | persistency of mesenteric ischemia clinical signs or of ischemic gastric stenosis | 2 years |
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