Acute Lymphatic Leukemia Clinical Trial
Official title:
Longitudinal Investigation of Hippocampal Function and Morphology in ALL Patients Treated With Chemotherapy: A Monocentric, Interdisciplinary Pilot Study
There are two regions in the adult brain that exhibit neuronal stem and progenitor cells,
generating new neurons postnatally and throughout adulthood. One is the so called
subventricular zone the other is the dentate gyrus of the hippocampus. Adult neurogenesis is
a physiological process representing an important functional impact for certain brain areas,
especially the hippocampus. The hippocampal formation plays an important role in long-term
memory and spatial navigation. Inhibition of adult neurogenesis in mice by chemotherapy or
radiation is followed by significant deficits in hippocampal memory functions while
hippocampus-independent memory is unaffected.
Clinical trials had shown that chemotherapy and brain radiation lead to cognitive
dysfunction. However, the exact mechanisms underlying this phenomenon are still
unidentified.
The aim of our study is to investigate, whether the inhibition of adult neural stem cell
proliferation in the hippocampus by intrathecal chemotherapy and/or cerebral radiation is
responsible for treatment induced memory deficits. We will investigate patients suffering
from acute lymphatic leukaemia (ALL) that receive prophylactic intrathecal chemotherapy and
brain irradiation. The study represents a longitudinal investigation including a virtual
"humanized" version of the morris-water-maze to test hippocampus dependent spatial memory,
as well as MR-imaging for morphological (volumetry) and biochemical (spectroscopy) data.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05250869 -
Comparative Quantification of MTX and Its Metabolites Post Glucarpidase
|