Acute Lung Injury Clinical Trial
— DELTAOfficial title:
Comparison of Different Positive End-expiratory Pressure Titration Strategies Using ELectrical Impedance Tomography in Patients With Acute Respiratory Distress Syndrome : the DELTA Physiological Study
Verified date | July 2022 |
Source | University Hospital, Angers |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The aim of the this study is to assess the short term physiological effects of 3 ventilation strategies for adult patients with ARDS admitted to intensive care unit. Two of those strategies are based on electrical impedance tomography (EIT) monitoring.
Status | Completed |
Enrollment | 22 |
Est. completion date | April 8, 2021 |
Est. primary completion date | April 8, 2021 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years and older |
Eligibility | Inclusion Criteria: - patients with moderate to severe ARDS, defined by the Berlin consensus, at 12 to 48h from diagnosis - PaO2/FiO2 ratio < 150 mmHg - Patient affiliated to or beneficiary of a health care plan - Consent obtained from patient's SDM Exclusion Criteria: - Pneumothorax - Contraindication to the insertion of a nasogastric tube with an esophageal balloon - Contraindication to the use of Electrical impedance tomography - Pregnancy, lactating or parturient woman |
Country | Name | City | State |
---|---|---|---|
France | CHU Angers | Angers |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Angers |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in PaO2 (mmHg) | As it is a physiological study, all the outcomes will be analyzed with the same importance! | Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes | |
Secondary | Change in PaCO2 (mmHg) | As it is a physiological study, all the outcomes will be analyzed with the same importance | Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes | |
Secondary | Plateau pressure (cmH2O) | As it is a physiological study, all the outcomes will be analyzed with the same importance | Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes | |
Secondary | Positive end expiratory pressure (cmH2O) | As it is a physiological study, all the outcomes will be analyzed with the same importance | Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes | |
Secondary | Expiratory and inspiratory transpulmonary pressure (cmH2O) | As it is a physiological study, all the outcomes will be analyzed with the same importance | Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes | |
Secondary | Regional ventilation distribution (%) | As it is a physiological study, all the outcomes will be analyzed with the same importance | Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes | |
Secondary | Center of ventilation (%) | As it is a physiological study, all the outcomes will be analyzed with the same importance | Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes | |
Secondary | Overdistension and collapsus (%) | As it is a physiological study, all the outcomes will be analyzed with the same importance | Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes | |
Secondary | Global and regional end expiratory lung impedance changes (IU) | As it is a physiological study, all the outcomes will be analyzed with the same importance | Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes | |
Secondary | End expiratory lung volume (mL) | As it is a physiological study, all the outcomes will be analyzed with the same importance | Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes | |
Secondary | Blood pressure (mmHg) | As it is a physiological study, all the outcomes will be analyzed with the same importance | Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes | |
Secondary | Heart rate (bpm) | As it is a physiological study, all the outcomes will be analyzed with the same importance | Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes | |
Secondary | Cardiac output (L/min) | As it is a physiological study, all the outcomes will be analyzed with the same importance | Time : 0 ; 45 minutes ; 90 minutes ; 135 minutes ; 180 minutes |
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