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NCT06353659 Clinical Trial

The Diagnostic Value of Contrast-enhanced Ultrasound in Acute Kidney Injury in ICU

Acute Kidney Injury Clinical Trial

Official title:
The Diagnostic Value of Contrast-enhanced Ultrasound in Acute Kidney Injury in Intensive Care Unit

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT06353659
Other study ID # M2024077
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date April 15, 2024
Est. completion date June 30, 2026

Study information
Verified date April 2024
Source Peking University Third Hospital
Contact Yuewei Zhang, Dr
Phone 18800109082
Email zhang_yue_wei@126.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The goal of this observational study is to quantitatively assess the renal microcirculation changes by contrast-enhanced ultrasound (CEUS) and to obtain systemic hemodynamic information by ultrasound Doppler at the same time, to analyze the relationship between renal microcirculation changes and systemic hemodynamic changes, and to explore the diagnostic value of CEUS in critically ill acute kidney injury.

Description:

The main questions it aims to answer are: 1. To explore the quantitative parameters of contrast-enhanced ultrasound which can reflect the changes of renal microcirculation。 2. To explore the relationship between renal microcirculation and systemic hemodynamics。 3. To explore the value of quantitative evaluation of renal microcirculation changes by contrast-enhanced ultrasound in the diagnosis of acute kidney injury

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 60
Est. completion date June 30, 2026
Est. primary completion date June 30, 2025
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Age>18 years old - First admission to ICU < 24h after admission and expected ICU stay =48 hours - Acute kidney injury risk factors (KDIGO 2012) - Contrast-enhanced ultrasound Exclusion Criteria: - Known severe chronic kidney disease (CKD= stage 4) or undergoing hemodialysis treatment - Kidney transplantation or renal malignancy - Terminal stage of malignant tumor - Pregnancy - Renal artery stenosis or renal vein thrombosis - The quality of CEUS images is poor, and quantitative analysis cannot be performed

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Contrast-enhanced Ultrasound
Patients with acute kidney injury high risk factors (KDIGO 2012) will undergo a contrast-enhanced ultrasound within 24 hours of admission to the ICU

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Peking University Third Hospital

Outcome
Type Measure Description Time frame Safety issue
Primary Acute kidney injury (according to KDIGO 2012 criteria) Acute kidney injury occur or not Through study completion, an average of 7 days
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