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Retrospective Registry Study of Patients With Cancer Treated With High-dose Methotrexate

Acute Kidney Injury Clinical Trial

Official title:
High-dose Methotrexate Patterns of Use, Clearance, Toxicities, Supportive Care and Outcomes

Clinical Trial Summary

This retrospective observational study will evaluate high-dose methotrexate patterns of use, supportive care measures used during high-dose methotrexate chemotherapy, along with the incidence of delayed elimination of methotrexate, acute kidney injury and any associated impact of delayed elimination of methotrexate on future courses of chemotherapy and disease outcomes in adults and children with cancer. The study will compare current practice with existing guidelines and best practices to identify potential gaps in the management of high-dose methotrexate administration and delayed elimination of methotrexate. The study will identify variations in practice and outcomes in different study centers, countries, cancer types, patient age groups, by different methotrexate doses and infusion times and different supportive care measures used. The study will also document the proportion of high-dose methotrexate courses in which glucarpidase has been used and any toxicities attributable to the use of glucarpidase.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05899751
Study type Observational
Source BTG International Inc.
Contact Lois Wallace
Phone +1 945 239 1690
Email Lois.wallace@btgsp.com
Status Recruiting
Phase
Start date April 1, 2022
Completion date December 2023
View Details
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