Machine Learning Predict Renal Replacement Therapy After Cardiac Surgery

Acute Kidney Injury Clinical Trial

Official title:

Using Machine Learning to Predict Acute Kidney Injury Requiring Renal Replacement Therapy After Cardiac Surgery

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04977687
• Other study ID #: chinaPLAGH-08983219
• Status: Completed
• Start date: September 1, 2020
• Est. completion date: January 1, 2021

Study information

• Verified date: July 2021
• Source: Chinese PLA General Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Cardiac surgery-associated acute kidney injury (CSA-AKI) is a major complication which may result in adverse impact on short- and long-term mortality. The researcher here developed several prediction models based on machine learning technique to allow early identification of patients who at the high risk of unfavorable kidney outcomes. The retrospective study comprised 2108 consecutive patients who underwent cardiac surgery from January 2017 to December 2020.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 2108
• Est. completion date: January 1, 2021
• Est. primary completion date: January 1, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• age over 18 years who underwent cardiac surgery

Exclusion Criteria:

• data miss greater than 10%

Related Conditions & MeSH terms

• Acute Kidney Injury
• Machine Learning
• Prediction Models
• Renal Replacement Therapy

Locations

Country	Name	City	State
China	Chinese PLA General hospital	Beijing	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Chinese PLA General Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	patients required renal replacement therapy	The primary outcome was patients with the requirement for acute dialysis within 14 days after cardiac surgery. Renal replacement therapy is recommended for patients with severe acute kidney injury as well as hemodynamic instability or severe electrolyte disturbances (e.g. blood potassium > 6) or acid-base balance disturbances (e.g. H value less than or equal to 7.15).; Prior to the start of renal replacement therapy, the investigator invited a consultation with the nephrology department to assess the condition	14 days