The Relationship Between Hypoalbuminemia and Development of Acute Kidney Failure (AKI) According to KDIGO Criteria

Acute Kidney Failure Clinical Trial

Official title:

The Relationship Between Preoperative and Postoperative Hypoalbuminemia and Development of Acute Kidney Failure (AKI) According to KDIGO Criteria in Advanced Age Hip Kidney Surgery

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT03675906
• Other study ID #: ERZINCAN BINALI YILDIRIM
• Status: Active, not recruiting
• Start date: September 12, 2018
• Est. completion date: December 30, 2018

Study information

• Verified date: September 2018
• Source: Erzincan University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study was designed to determine the association between preoperative and postoperative hypoalbuminemia and AKI in older age hip fracture surgeons, to determine which period of hypoalbuminemia contributes more to AKI development, the incidence of AKI according to anesthesia type, the presence of other factors affecting AKI development, the duration of hospitalization and cost- to be investigated.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 160
• Est. completion date: December 30, 2018
• Est. primary completion date: December 15, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 65 Years and older

Eligibility

Inclusion Criteria:

• patients with femur fracture surgery

• 65 years and over

• Patients with ASA I - IV physical condition

• patients with spinal anesthesia or peripheral nerve block

Exclusion Criteria:

• Patients undergoing emergency surgery

• patients with preoperative serum creatinine (sCr) level> 1.5 mg / dl

• patients with low serum albumin levels in both preoperative and postoperative periods

• patients receiving preoperative ventilator care

• patients with spinal anesthesia or peripheral nerve block contraindications (coagulopathies, local infection at the puncture site, spot infection) or nonsteroidal antiinflammatory drug (NSAID)

Related Conditions & MeSH terms

• Acute Kidney Failure
• Acute Kidney Injury
• Hypoalbuminemia
• Renal Insufficiency

Intervention

Other:
• hypoalbuminemia
hypoalbuminemia and acute kidney injury

Locations

Country	Name	City	State
Turkey	Erzincan University	Erzincan

Sponsors (1)

Lead Sponsor	Collaborator
Erzincan University

Country where clinical trial is conducted

Turkey, 

References & Publications (4)

Kim HJ, Koh WU, Kim SG, Park HS, Song JG, Ro YJ, Yang HS. Early postoperative albumin level following total knee arthroplasty is associated with acute kidney injury: A retrospective analysis of 1309 consecutive patients based on kidney disease improving g — View Citation

Kim K, Bang JY, Kim SO, Kim S, Kim JU, Song JG. Association of preoperative hypoalbuminemia with postoperative acute kidney injury in patients undergoing brain tumor surgery: a retrospective study. J Neurosurg. 2018 Apr;128(4):1115-1122. doi: 10.3171/2016 — View Citation

Section 2: AKI Definition. Kidney Int Suppl (2011). 2012 Mar;2(1):19-36. — View Citation

Shin KH, Han SB. Early postoperative hypoalbuminemia is a risk factor for postoperative acute kidney injury following hip fracture surgery. Injury. 2018 Aug;49(8):1572-1576. doi: 10.1016/j.injury.2018.05.001. Epub 2018 May 2. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	hypoalbuminemia and AKI - incidence of AKI	hypoalbuminemia and incidence of AKI according to KDIGO criterias	3 months
Secondary	anesthesia type - incidence of AKI	incidence of AKI according to anesthesia type	3 months