Acute Coronary Syndrome Clinical Trial
The primary objective of this study is to propose new treatment algorithm (strategy) for patients with Acute Coronary Syndrome (ACS) and left bundle-branch block (LBBB).
Current recommendations on the treatment of acute coronary syndrome (ACS) dictate urgent
reperfusion therapy in the case of evolving myocardial infarction with ST-segment elevation
(STEMI). Optimal use of PCI (preferably) or thrombolysis in this situation requires a rapid
and correct diagnosis.
According to the ESC'2008 and ACC/AHA'2009 focused update guidelines patients admitted to
the hospital within 12 hours after the onset of chest pain with new (or presumably new) left
bundle-branch block (LBBB) should be treated like patients having STEMI (class I, level A).
However, it is well-known that in patients with concomitant LBBB, the ECG manifestations of
acute myocardial injury may be masked.
ACS may occur in a patient with "true old" LBBB (when doctor has/has not an ability to
compare the new ECG with the previous one) or (presumably) new LBBB.
There is a high risk of non receiving appropriate therapy or of receiving inappropriate
therapy (thrombolysis instead of LMWH/UFH/fondaparinux).
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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