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Actinic Keratosis clinical trials

View clinical trials related to Actinic Keratosis.

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NCT ID: NCT06319794 Recruiting - Actinic Keratosis Clinical Trials

Study on the Safety and Efficacy of Bimiralisib Gel in Participants Suffering From Actinic Keratosis

Start date: April 2, 2024
Phase: Phase 2
Study type: Interventional

The aim of the study is to evaluate efficacy and safety of bimiralisib gel treatment for treatment of actinic keratosis (AK) on the face and/or scalp and/or back of hands

NCT ID: NCT06027619 Recruiting - Actinic Keratosis Clinical Trials

Short Contact Protocols to Reduce Pain During 10% ALA Gel Red-light Photodynamic Therapy of Actinic Keratoses

Start date: October 2, 2023
Phase: Phase 2
Study type: Interventional

The goal of this clinical trial is to see if shorter Photodynamic Therapy (PDT) treatment times will still be effective at treating actinic keratoses (AK) while reducing or eliminating the pain that patients sometimes experience during conventional PDT treatment. The main questions it aims to answer are: - Will the application of the nanoemulsion (10% ALA gel), in the absence of occlusion, still achieve significant inflammation and lesion clearance? - Will shortened incubation times of Ameluz still achieve significant inflammation and lesion clearance? - Will the new test regimens achieve reduced pain during illumination? - Will the new test regimens be safe? Participants will be randomly assigned to one of three treatment regimens, which will determine the length of time that the topical medication will incubate on the face before red light exposure in PDT treatments. The incubation period will be either 10 minutes, 20 minutes, or 60 minutes.

NCT ID: NCT05699603 Recruiting - Actinic Keratosis Clinical Trials

Testing the Efficacy of Topical Calcipotriene Plus 5-Fluorouracil Combination to Activate the Immune System Against Precancerous Skin Lesions in Organ Transplant Recipients

Start date: August 18, 2024
Phase: Phase 2
Study type: Interventional

This phase IIA study evaluates the effects of calcipotriene plus 5- fluorouracil immunotherapy for skin cancer prevention in organ transplant recipients. Precancerous skin lesions, actinic keratoses (AK), may put organ transplant recipients at higher than average risk of developing skin cancer. Topical calcipotriene is a form of vitamin D and is used to treat psoriasis and topical 5- fluorouracil is a chemotherapy agent applied to the skin. The combination of calcipotriene plus 5- fluorouracil topical cream, which activates the immune cells against cancer, may help prevent skin cancer in organ transplant recipients who have precancerous skin lesions.

NCT ID: NCT05688904 Recruiting - Actinic Keratosis Clinical Trials

The Effect of Topical Imipramine on Pain and Effectiveness of Topical Photodynamic Therapy

Start date: January 19, 2023
Phase: Phase 1
Study type: Interventional

The purpose of this study is testing the use of topical Imipramine in combination with topical photodynamic therapy's (PDT) effect on pain following treatment. PDT is a commonly used treatment in dermatology for patients who have many pre-cancers (actinic keratosis-AKs) on their skin. These are both FDA-approved treatments, but this study is evaluating their use in combination, which has not been evaluated in the past. The investigators have been doing studies using animals that suggest that imipramine might make the PDT less painful and might help it work better. In order to participate, the subject and their dermatologist have decided that they would benefit from PDT to treat their skin due to many AK precancerous lesions. Please note that neither PDT nor imipramine are experimental treatments, but treating their skin with imipramine before PDT is a new approach.

NCT ID: NCT04779255 Recruiting - Pain Clinical Trials

Pain Management During a Photodynamic Therapy Session on the Vertex for Actinic Keratosis: Tumescent Anesthesia Interest

ANTUKA
Start date: July 28, 2021
Phase: N/A
Study type: Interventional

This study focus on the efficacity of tumescent anesthesia in pain management during a photodynamic therapy on the vertex for treatment of actinic keratosis. To do this we carried out a prospective, randomized, controlled, open-ended study. Our aim is to show a 40% reduction in pain during photodynamic therapy session compared to a conventionally used analgesic method (paracetamol + cold water)

NCT ID: NCT04396184 Recruiting - Actinic Keratosis Clinical Trials

Conventional Photodynamic Therapy vs. Painless Photodynamic Therapy for Actinic Keratosis

Start date: May 1, 2020
Phase: N/A
Study type: Interventional

This study is being done to compare a new, continuous illumination and short Incubation time regimen of aminolevulinic acid photodynamic therapy#ALA-PDT) to a conventional regimen for treatment of Actinic Keratosis. The hypothesis is that the continuous illumination approach will be less or even no painful, but equally efficacious, as the old regimen.

NCT ID: NCT03684772 Recruiting - Actinic Keratosis Clinical Trials

Topical Ionic Contra-Viral Therapy in Actinic Keratosis

Start date: October 22, 2018
Phase: Phase 2
Study type: Interventional

To explore the pharmacodynamics and evaluate safety, tolerability and clinical efficacy of ICVT comprised of digoxin and furosemide (dual agent), digoxin (single agent), furosemide (single agent) in patients with AK.

NCT ID: NCT03013647 Recruiting - Actinic Keratosis Clinical Trials

Daylight Photodynamic Therapy for Actinic Keratosis and Skin Field Cancerization

Start date: September 2016
Phase: N/A
Study type: Interventional

Twenty patients with multiple actinic keratosis on the face will be enrolled in the study and will be treated with Daylight Photodynamic therapy. Before and after skin biopsies will be performed, for histological and immunohistochemical analysis.

NCT ID: NCT02759900 Recruiting - Actinic Keratosis Clinical Trials

Using a Cold Atmospheric Plasma Device to Treat Skin Disorders

Start date: January 2016
Phase: N/A
Study type: Interventional

This study examines the efficacy of a non-thermal, atmospheric plasma device in the treatment of skin disorders

NCT ID: NCT02647151 Recruiting - Actinic Keratosis Clinical Trials

Efficacy and Safety of Treatment of Actinic Keratoses With Photodynamic Therapy Between MAL Cream and ALA Gel

Start date: December 2015
Phase: Phase 4
Study type: Interventional

Photodynamic therapy technique (PDT) is a conventional technique which is performed applying the product under occlusion lesions, let it incubate for 3 hours and then exposed skin to a light source, usually red. The conclusions of efficacy, tolerance and satisfaction that today are known about PDT with MAL, but not with ALA, which is a new photosensitizer indicated for Actinic Keratoses. The pharmaceutical form of ALA is a gel, which gives a hypothetical better penetration and consequently it is more effectively.