Acne Vulgaris Clinical Trial
Official title:
A Randomized Study to Compare the Acne Relapse Rate After a 3-mo Course of Oral Minocycline, to a 3-mo Course of Oral Minocycline in Combination With a Daily Dose of Topical Tretinoin 0.01% Followed by 3 mo of Topical Tretinoin Alone
The use of oral antibiotics alone to treat inflammatory acne provides little to no long term
therapeutic benefit.
Acne relapse rates can be reduced by using topical tretinoin 0.01% in conjunction with
minocycline, thereby increasing the therapeutic effect of the oral antibiotic.
Although oral antibiotics have been the mainstay of treatment of inflammatory acne for 30
years, studies comparing their efficacy have little scientific value.
Evidence-based dermatology proves minocycline to be an effective treatment for acne vulgaris
while the patient remains on the medication; however, the relapse rate of acne after a
course of antibiotics has never been established.
The relapse rate would appear to be significant, as repeated courses and long-term
antibiotic use are commonly prescribed in practice. The increasing problem of drug
resistance has raised issues of the suitability of such long term antibiotic treatment and
this overuse is probably a contributing factor of multiple drug resistance in our society.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment
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