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Clinical Trial Summary

The Parasitic Ulcer Treatment Trial (PUTT) is a multi-center, parallel-group, randomized clinical trial. The purpose of this study is to determine whether including topical corticosteroids in a regimen for acanthamoeba keratitis (AK) will improve vision. Patients presenting to all enrollment centers with evidence of acanthamoeba keratitis will be eligible for the trial if there is evidence of ocular inflammation after 4 weeks of anti-amoebic therapy. Those who agree to participate will be randomized to one of two treatment groups: - Group 1: Topical corticosteroid - Group 2: Topical placebo


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT06213649
Study type Interventional
Source University of California, San Francisco
Contact Jeremy Keenan, MD, MPH
Phone 415-476-6323
Email jeremy.keenan@ucsf.edu
Status Not yet recruiting
Phase Phase 3
Start date April 2024
Completion date April 2028

See also
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Active, not recruiting NCT02506257 - Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects Phase 1
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Enrolling by invitation NCT03461978 - Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures N/A
Recruiting NCT02763605 - Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years N/A
Active, not recruiting NCT03484507 - Parasitic Ulcer Treatment Trial Pilot Phase 2
Active, not recruiting NCT05110001 - Rose Bengal Electromagnetic Activation With Green Light for Infection Reduction Phase 3
Completed NCT03274895 - Polihexanide (PHMB) Eye Drops in Patients Affected by Acanthamoeba Keratitis Phase 3