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Acanthamoeba Keratitis clinical trials

View clinical trials related to Acanthamoeba Keratitis.

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NCT ID: NCT03274895 Recruiting - Clinical trials for Acanthamoeba Keratitis

Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis

Start date: August 13, 2017
Phase: Phase 3
Study type: Interventional

Phase 3 study to evaluate the efficacy, safety and tolerability of 0.08% PHMB ophthalmic solution in subjects affected by Acanthamoeba keratitis. A total of 130 subjects will be assigned to one of the following 2 treatment groups: Group 1: 0.08% PHMB + placebo Group 2: 0.02% PHMB + 0.1% propamidine combination therapy

NCT ID: NCT02763605 Recruiting - Clinical trials for Acanthamoeba Keratitis

Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years

Start date: January 2014
Phase: N/A
Study type: Observational

Acanthamoebic keratitis is an important corneal disease which may cause severe complication. The difficulty in diagnosis, the difficulty in treatment, and the long treatment process are factors leading to the poor prognosis of these patients. In this retrospective study, the investigators try to analyze the tissue proven Acanthamoebic keratitis diagnosed in our hospital. The investigators will focus on the in vivo confocal microscopic results, the medical history and the medical/surgical treatment outcome. The investigators will collect the tissue proven cases according to the data provided by laboratory diagnosis department and pathological department. The in vivo confocal microscopic results will be collected and analyzed. The investigators will also look through the photography of the external eyes from data stored in PAC system. The medical history and treatment outcome will be studied from clinical chart review. From this study, the investigators aimed to find out a easy way of diagnosing Acanthamoebic keratitis from in vivo confocal microscopy, and find out a better way for treatment.

NCT ID: NCT02506257 Active, not recruiting - Clinical trials for Acanthamoeba Keratitis

Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects

Start date: November 2015
Phase: Phase 1
Study type: Interventional

Randomized, double-masked, placebo-controlled, multiple center, parallel-group Phase 1 study to evaluate the safety and tolerability of 3 doses of preservative-free PHMB ophthalmic solution compared to placebo in healthy subjects