Abscess Clinical Trial
Official title:
The Use of Adjuvant Antibiotic Therapy After Incision and Drainage for Pediatric Abscess: A Prospective, Randomized, Double-blinded, Placebo-Controlled Trial
Background: Skin abscesses are a growing problem in the general pediatric population around
the world. While the standard treatment for an abscess/boil is incision and drainage, many
physicians also prescribe antibiotics, despite the lack of evidence that antibiotics are
necessary to help the wound heal. The purpose of this research study is to determine whether
antibiotics are necessary after incision and drainage of a skin abscess in children. This is
an important question because medical evidence has shown that using antibiotics when they are
not needed has contributed to the increase of bacterial antibiotic resistance. In fact,
several of the antibiotics that successfully killed Staph bacteria several years ago are now
no longer effective because of antibiotic resistance. Now resistant forms of Staph bacteria,
called "Community-Acquired Methicillin-Resistant Staph Aureus" (CA-MRSA), account for 50-85%
of all pediatric skin abscesses. If antibiotics are not necessary then withholding them when
appropriate may help slow the progression of antibiotic-resistant Staph infections.
Objective(s) and Hypothesis(es): The investigators believe that antibiotics are no better
than placebo at achieving a cure after drainage of an abscess in a child. The objective of
this study is to answer the question: Do antibiotics after abscess drainage result in a
better chance of cure than placebo?
Potential Impact: If abscess drainage alone is shown to be as effective as drainage followed
by antibiotics, then the routine use of antibiotics for this problem could be avoided. This
would help limit the increasing antibiotic resistance of bacteria (especially CA-MRSA) in
communities around the world. A well-designed study may provide the evidence to change the
way children are treated for abscesses in a future where antibiotic resistant bacteria will
be even more of a public health challenge.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03127371 -
Adjunctive Nitrous Oxide During ED Incision and Drainage of Abscess
|
N/A | |
| Completed |
NCT02240498 -
Safety and Feasibility Study of Methylene Blue Photodynamic Therapy to Sterilize Deep Tissue Abscess Cavities
|
Phase 1 | |
| Completed |
NCT00746109 -
Study of Wound Packing After Superficial Skin Abscess Drainage
|
Phase 4 | |
| Completed |
NCT00402727 -
Comparison of Sequential IV/PO Moxifloxacin With IV Piperacillin/Tazobactam Followed by PO Amoxicillin/Clavulanic Acid in Patients With a Complicated Skin and Skin Structure Infection
|
Phase 3 | |
| Completed |
NCT00352612 -
Comparison of Cephalexin Versus Clindamycin for Suspected CA-MRSA Skin Infections
|
Phase 4 | |
| Completed |
NCT00137085 -
Ketamine Versus Fentanyl as an Adjunct to Propofol-Assisted Emergency Department Procedural Sedation
|
N/A | |
| Completed |
NCT02714023 -
Water And Saline Head-to-head In The Blinded Evaluation Study Trial
|
N/A | |
| Completed |
NCT02264392 -
US Guided Versus BlindI&D for Treatment of Soft Tissue Abscesses in the ED
|
N/A | |
| Active, not recruiting |
NCT05226260 -
Decreasing Antibiotic Duration for Skin and Soft Tissue Infection Using Behavioral Economics in Primary Care
|
N/A | |
| Withdrawn |
NCT04241471 -
Incision and Loop Drainage Utilizing a Novel Technique for Management of Cutaneous Abscess in an Adult Population
|
N/A | |
| Recruiting |
NCT06284473 -
Ketamine as a Supplement to Local Anesthesia for Minor Procedures
|
Phase 4 | |
| Completed |
NCT01235546 -
Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection
|
N/A | |
| Not yet recruiting |
NCT03917134 -
Prevention of Vaginal Cellulitis or Vaginal Cuff Abscess After Laparoscopic Hysterectomy
|
N/A | |
| Withdrawn |
NCT02703233 -
Effectiveness of Nitrous Oxide in the ED
|
Phase 4 | |
| Completed |
NCT01557426 -
Soft Tissue Ultrasound of Infections
|
Phase 1 | |
| Completed |
NCT01339091 -
Efficacy and Safety of Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections
|
Phase 3 | |
| Terminated |
NCT00867789 -
Antibiotics Versus Placebo in the Treatment of Abscesses in the Emergency Department
|
N/A | |
| Completed |
NCT01784458 -
Clinical Significance of Intra-abdominal Hypertension in Surgical Patients With Severe Sepsis
|
N/A | |
| Completed |
NCT00984022 -
Aquacel Versus Iodoform Gauze for Filling Abscess Cavity Following Incision and Drainage
|
Phase 2 | |
| Completed |
NCT05204537 -
The Role of Surgery in Patients With Coronavirus Disease - 19 (COVID-19) Related Thoracic Complications
|