Abortion Clinical Trial
Official title:
Side Effects and Adherence Associated With Doxycycline Use Following Medical Abortion
The effectiveness of antibiotic treatment at reducing post-abortion infection is unclear. The experiences of women prescribed routine antibiotics after medical abortion is missing from the existing evidence. This study seeks to add to the literature evidence of the side effects associated with antibiotic treatment that women experience and their adherence to prescribed regimens.
Medical abortion (MA) consists of administering medication, typically a combination of
mifepristone and misoprostol, to induce an abortion without any invasive procedures. Early
first trimester MA is effective1, highly acceptable to women, and safe. The risk of
infection following medical abortion is small, at less than 1%. In rare circumstances,
pelvic infection with clostridia bacteria following medical abortion has resulted in death.
Since 2000, when mifepristone was registered in the United States, 8 such deaths have been
recorded in the US.
Following the publication of case reports of four clostridium-associated deaths after
medical abortion in 2005, the reproductive health community reacted swiftly. Medical
abortion protocols were altered in an effort to curb these drastic and rapidly fatal
infections. Antibiotic treatment, typically a seven-day course of doxycycline, has become
widespread in the United States.
The effectiveness of antibiotic treatment at reducing post-abortion infection is unclear.
The experiences of women prescribed routine antibiotics after medical abortion is missing
from the existing evidence. This study seeks to add to the literature evidence of the side
effects associated with antibiotic treatment that women experience and their adherence to
prescribed regimens.
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