Abdominal Cancer Clinical Trial
Official title:
Safety and Efficacy of Intrathecal Morphine in Children Undergoing Major Abdominal Surgeries, Dose-finding Clinical Study
Postoperative pain in pediatrics can usually be well controlled with a combination of analgesics including acetaminophen ( paracetamol) ,NSIADS, opioids , and local/regional anesthesia.The use of epidural and subarachnoid morphine for analgesia in adults has grown almost as quickly as Morton`s discovery of anesthesia in 1846. The application of these techniques to the pediatric patients has evolved much more slowly,although significant progress is being made by many investigators.
Advantage of intrathecal morphine as that extremely small doses of opioids are required when
administrated intrathecally because they have direct access to spinal cord opioid receptors.
Drug administered epidurally or caudally are required in much higher doses because they must
first diffuse into the CSF before they reach spinal opioid receptors. As a result, the
duration of action of intrathecal morphine is greater than that of single shot peridural
techniques.
To investigate the safety and efficacy of intrathecal morphine in post operative pain relief
in pediatric patients undergoing major abdominal cancer surgeries using different doses of
intrathecal morphine (2 μg/kg , 5 μg/kg ,10μg/kg).
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